Genetic variability of principal neutralizing determinants on HIV-1 gp41 and its correlation with subtypes

被引：6
|
作者：
Dong, XN [1 ]
Ying, H [1 ]
Wu, Y [1 ]
Chen, YH [1 ]
机构：
[1] Tsing Hua Univ, Immunol Lab, Dept Biol, Prot Sci Lab MOE, Beijing 100084, Peoples R China
来源：
IMMUNOLOGY LETTERS | 2005年 / 101卷 / 01期
关键词：
HIV-1; gp41; genetic variability; subtype; neutralizing epitopes;
D O I：
10.1016/j.imlet.2005.04.013
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Several neutralizing determinants have been identified on HIV-1 envelope glycoprotein gp41: LGIWGCSGKLIC (HXB2: aa593-604), ELDKWA (aa662-667), NWFDIT (aa671-676), and ERDRDR (aa739-744). Restricted mutations were observed on these epitopes. In this study, the genetic variability of these neutralizing determinants in 3799 isolates from different M-group subtypes (A, B, C, D, F, G, H, CRF01_AE and CRF02_AG) and 0 group was analyzed. Many variants were found to be closely correlated with certain subtypes. These subtype-related variants could be recruited into the subtype identification and subtype-specific vaccine development. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码：104 / 107
页数：4
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