Acidic Ca2+ stores come to the fore

被引:58
作者
Patel, Sandip [1 ]
Muallem, Shmuel [2 ]
机构
[1] UCL, Dept Cell & Dev Biol, London WC1E 6BT, England
[2] NIDCR, Epithelial Signaling & Transport Sect, Mol Physiol & Therapeut Branch, NIH, Bethesda, MD 20892 USA
基金
英国生物技术与生命科学研究理事会;
关键词
Calcium; Acidic calcium stores; Acidocalcisomes; Vacuoles; Endosomes; Lysosomes; Lysosome-related organelles; Secretory vesicles; Golgi; TRP channels; Two-pore channels; TPCs; IP3; receptor; Ryanodine receptor; Ca2+ ATPases; Ca2+/H+ exchangers; NAADP; Acute pancreatitis; Lysosomal storage disorders; Protists; Trypanosomes; Plants; Yeast; Sea urchin; Platelets; Pancreatic acinar cells; MUCOLIPIDOSIS TYPE-IV; SEA-URCHIN EGGS; ENDOPLASMIC-RETICULUM; CALCIUM; NAADP; CHANNEL; RELEASE; CELLS; ORGANELLES; GOLGI;
D O I
10.1016/j.ceca.2011.03.009
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Changes in the concentration of cytosolic Ca2+ form the basis of a ubiquitous signal transduction pathway. Accumulating evidence implicates acidic organelles in the control of Ca2+ dynamics in organisms across phyla. In this special issue, we discuss Ca2+ signalling by these "acidic Ca2+ stores" which include acidocalcisomes, vacuoles, the endo-lysosomal system, lysosome-related organelles, secretory vesicles and the Golgi complex. Ca2+ release from these morphologically very different organelles is mediated by members of the TRP channel superfamily and two-pore channels. Inositol trisphosphate and ryanodine receptors which are traditionally viewed as endoplasmic reticulum Ca2+ release channels can also mobilize acidic Ca2+ stores. Ca2+ uptake into acidic Ca2+ stores is driven by Ca(2+)ATPases and Ca2+/H+ exchangers. In animal cells, the Ca2+-mobilizing messenger NAADP plays a central role in mediating Ca2+ signals from acidic Ca2+ stores through activation of two-pore channels. These signals are important for several physiological processes including muscle contraction and differentiation. Dysfunctional acidic Ca2+ stores have been implicated in diseases such as acute pancreatitis and lysosomal storage disorders. Acidic Ca2+ stores are therefore emerging as essential components of the Ca2+ signalling network and merit extensive further study. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码:109 / 112
页数:4
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