Two new nor-lignans, siamensinols A and B, from Selaginella siamensis Hieron. and their biological activities

被引：3
作者：
Thamnarak, Wanlaya [1 ]
Eurtivong, Chatchakorn [2 ]
Pollawatn, Rossarin [3 ]
Ruchirawat, Somsak [1 ,2 ,4 ]
Thasana, Nopporn [1 ,2 ,4 ]
机构：
[1] Chulabhorn Res Inst, Lab Med Chem, Bangkok, Thailand
[2] Chulabhorn Royal Acad, Chulabhorn Grad Inst, Program Chem Sci, Bangkok, Thailand
[3] Chulalongkorn Univ, Fac Sci, Dept Bot, Plant Thailand Res Unit, Bangkok, Thailand
[4] Commiss Higher Educ, Minist Educ, Ctr Excellence Environm Hlth & Toxicol, Bangkok, Thailand
来源：
NATURAL PRODUCT RESEARCH | 2022年 / 36卷 / 21期
关键词：
Selaginellaceae; Selaginella siamensis Hieron; siamensinol; nor-lignan; cancer chemoprevention; cytotoxicity; PHENYLPROPANOIDS; BIFLAVONOIDS; DERIVATIVES; ANTIOXIDANT; GLYCOSIDES; CHROMONE; PLANTS;
D O I：
10.1080/14786419.2021.2022664
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Two new nor-lignans siamensinols A-B (1-2) and seven known compounds agatharesinol (3), syringaresinol-glucoside (4), noreugenin (5), 8-methyleugenitol (6), melachromone (7), uncinoside A (8) and daucosterol (9) were isolated from Selaginella siamensis Hieron. The structures of the new compounds were elucidated on the basis of comprehensive spectroscopic methods, including 1 D, 2 D-NMR, HR-ESI-MS and CD spectrometry. Compounds 1-2 showed moderate inhibitory effect on MOLT-3 cells while 8-methyleugenitol (6) exhibited moderate inhibitory effect on three tumor cells (HepG2, A549 and HuCCA-1). Compounds 2-3 showed the potent cancer chemoprevention in DPPH, XXO, IXO and AIA assays.
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页码：5591 / 5599
页数：9
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