Treatment approaches of gastrointestinal dysfunction in Parkinson's disease, therapeutical options and future perspectives

被引：15

作者：

Woitalla, D. ^{[1
]}

Goetze, O. ^{[2
]}

机构：

[1] Ruhr Univ Bochum, Dept Neurol, St Josef Hosp, D-44791 Bochum, Germany

[2] Univ Zurich Hosp, Div Gastroenterol & Hepatol, Zurich, Switzerland

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2011年 / 310卷 / 1-2期

关键词：

Gastrointestinal dysfunction; Treatment options; Enteric nervous system; Gastroparesis; Parkinson's disease; ENTERIC NERVOUS-SYSTEM; PLACEBO-CONTROLLED TRIAL; FUNCTIONAL DYSPEPSIA; LEWY BODIES; RESPONSE FLUCTUATIONS; CHRONIC CONSTIPATION; HEALTHY-VOLUNTEERS; NONMOTOR SYMPTOMS; GASTRIC-MOTILITY; 5-HT4; AGONIST;

D O I：

10.1016/j.jns.2011.06.050

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Gastrointestinal (GI) dysfunction is a common but underestimated feature in Parkinson's disease (PD). Out of the multimodal spectrum of treatment options, there currently are only a few pharmacological treatments available to improve gastrointestinal motility and symptoms. Because enteric nervous function is mainly regulated by transmitters different from those involved in the brain, dopamine replacement is not a treatment option in PD patients. This article focuses on the known regulative mechanism of Cl function and presents known and upcoming treatment options for GI dysfunction in PD. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：152 / 158

页数：7

共 102 条

[1] Frequency of bowel movements and the future risk of Parkinson's disease [J].

Abbott, RD ;

Petrovitch, H ;

White, LR ;

Masaki, KH ;

Tanner, CM ;

Curb, JD ;

Grandinetti, A ;

Blanchette, PL ;

Popper, JS ;

Ross, GW .

NEUROLOGY, 2001, 57 (03) :456-462

[2] Bowel movement frequency in late-life and incidental Lewy bodies [J].

Abbott, Robert D. ;

Ross, G. Webster ;

Petrovitch, Helen ;

Tanner, Caroline M. ;

Davis, Daron G. ;

Masaki, Karnal H. ;

Launer, Lenore J. ;

Curb, J. David ;

White, Lon R. .

MOVEMENT DISORDERS, 2007, 22 (11) :1581-1586

[3]

Albanese A, 2003, AM J GASTROENTEROL, V98, P1439

[4] Prokinetic Agents and QT Prolongation: A Familiar Scene with New Actors [J].

Alberto Keller, Guillermo ;

Di Girolamo, Guillermo .

CURRENT DRUG SAFETY, 2010, 5 (01) :73-78

[5] Loss of enteric dopaminergic neurons and associated changes in colon motility in an MPTP mouse model of Parkinson's disease [J].

Anderson, Grant ;

Noorian, All Reza ;

Taylor, Georgia ;

Anitha, Mallappa ;

Bernhard, Doug ;

Srinivasan, Shanthi ;

Greene, James G. .

EXPERIMENTAL NEUROLOGY, 2007, 207 (01) :4-12

[6] Increased gastric motility during 5-HT4 agonist therapy reduces response fluctuations in Parkinson's disease [J].

Asai, H ;

Udaka, F ;

Hirano, M ;

Minami, T ;

Oda, M ;

Kubori, T ;

Nishinaka, K ;

Kameyama, M ;

Ueno, S .

PARKINSONISM & RELATED DISORDERS, 2005, 11 (08) :499-502

[7] CLINICAL AND PHARMACOKINETIC EFFECTS OF A DIET RICH IN INSOLUBLE FIBER ON PARKINSON DISEASE [J].

ASTARLOA, R ;

MENA, MA ;

SANCHEZ, V ;

DELAVEGA, L ;

DEYEBENES, JG .

CLINICAL NEUROPHARMACOLOGY, 1992, 15 (05) :375-380

[8] Patient Characteristics and Treatment Outcome in Functional Anorectal Pain [J].

Atkin, Gary K. ;

Suliman, Amna ;

Vaizey, Carolynne J. .

DISEASES OF THE COLON & RECTUM, 2011, 54 (07) :870-875

[9] Ghrelin gastrokinetic action in patients with neurogenic gastroparesis [J].

Binn, M. ;

Albert, C. ;

Gougeon, A. ;

Maerki, H. ;

Coulie, B. ;

Lemoyne, M. ;

Lhoret, R. Rabasa ;

Tomasetto, C. ;

Poitras, P. .

PEPTIDES, 2006, 27 (07) :1603-1606

[10] Prucalopride accelerates gastrointestinal and colonic transit in patients with constipation without a rectal evacuation disorder [J].

Bouras, EP ;

Camilleri, M ;

Burton, DD ;

Thomforde, G ;

McKinzie, S ;

Zinsmeister, AR .

GASTROENTEROLOGY, 2001, 120 (02) :354-360

← 1 2 3 4 5 6 7 8 9 10 →