Synthesis and Biological Activities of Organotin(IV) Complexes as Antitumoral and Antimicrobial Agents. A Review

被引：48

作者：

Shah, Syed Shoaib Ahmad ^{[1
,2
]}

Ashfaq, Muhammad ^{[2
]}

Waseem, Amir ^{[1
]}

Ahmed, M. Mehboob ^{[2
]}

Najam, Tayyaba ^{[2
]}

Shaheen, Salma ^{[2
]}

Rivera, Gildardo ^{[3
]}

机构：

[1] Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan

[2] Islamia Univ Bahawalpur, Dept Chem, Bahawalpur, Pakistan

[3] Inst Politecn Nacl, Ctr Biotecnol Genom, Reynosa 88710, Mexico

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2015年 / 15卷 / 05期

关键词：

Agents; antimicrobial; antitumoral; synthesis; organotin(IV); N-BUTYLTIN DICHLORIDE; SPECTROSCOPIC CHARACTERIZATION; STRUCTURAL-CHARACTERIZATION; ORGANOMETALLIC POLYMERS; SONOCHEMICAL SYNTHESIS; INTERFACIAL TECHNIQUE; MOLECULAR-STRUCTURE; ANTIFUNGAL ACTIVITY; CELL-PROLIFERATION; CRYSTAL-STRUCTURE;

D O I：

10.2174/138955751505150408142958

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Advances in the use of organotin(IV) compounds have gained relevant interest in both the chemical and pharmaceutical industry. Tin(IV) form stable complexes with a unique structure and physicochemical properties that are used in organic synthesis as heat stabilizers and catalysts, in drug development as biologically active agents, and in other areas. This review focuses on recent progress in the classical and convenient synthesis procedure, on their mechanism of action, and biological activities as antitumoral and antimicrobial agents.

引用

页码：406 / 426

页数：21

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