Risk factors for multiple sclerosis and associations with anti-EBV antibody titers

被引：25

作者：

Mouhieddine, Tarek H. ^{[1
]}

Darwish, Hata ^{[1
]}

Fawaz, Lama ^{[1
]}

Yamout, Bassem ^{[1
]}

Tannim, Hani ^{[2
]}

Khoury, Samia J. ^{[1
]}

机构：

[1] Amer Univ, Med Ctr, Multiple Sclerosis Ctr, Abd Haidar Neurosci Inst, Beirut, Lebanon

[2] Amer Univ, Med Ctr, Clin Res Inst, Beirut, Lebanon

来源：

CLINICAL IMMUNOLOGY | 2015年 / 158卷 / 01期

基金：

芬兰科学院;

关键词：

Multiple sclerosis; Epstein-Barr virus; Risk factors; EPSTEIN-BARR-VIRUS; VITAMIN-D; DISEASE-ACTIVITY; CEREBROSPINAL-FLUID; HYPOVITAMINOSIS-D; IMMUNE-RESPONSE; NUCLEAR ANTIGEN; INFECTION; SMOKING; IGG;

D O I：

10.1016/j.clim.2015.03.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Multiple sclerosis (MS) is an inflammatory demyelination of the central nervous system. We investigated the prevalence of EBV seropositivity and other known risk factors for MS (age, smoking, low vitamin D) and their effect on anti-EBV antibody titers. We retrospectively studied 249 MS patients receiving care at the American University of Beirut Medical Center and 230 controls, during 2010-2014. EBV seropositivity was higher in MS patients compared to controls for both anti-VCA (99.5%; 97.2%) and anti-EBNA-1 (96.3%; 89.4%), and the titers were significantly higher in MS patients. MS patients had a significantly lower vitamin D level (15.5 +/- 8.3 ng/ml) compared to controls (20.4 +/- 11.3 ng/ml). The proportion of heavy smokers and overweight individuals was significantly higher in MS patients. Lebanese MS patients have risk factors similar to those in western countries. Older age and female gender were associated with a higher anti-VCA titer and male gender with a higher anti-EBNA-1. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：59 / 66

页数：8

共 50 条

[21] Combinatorial antibody library from multiple sclerosis patients reveals antibodies that cross-react with myelin basic protein and EBV antigen [J].

Gabibov, Alexander G. ;

Belogurov, Alexey A., Jr. ;

Lomakin, Yakov A. ;

Zakharova, Maria Yu ;

Avakyan, Marat E. ;

Dubrovskaya, Viktorya V. ;

Smirnov, Ivan V. ;

Ivanov, Alexis S. ;

Molnar, Andrey A. ;

Gurtsevitch, Vladimir E. ;

Diduk, Sergey V. ;

Smirnova, Ksenia V. ;

Avalle, Berangere ;

Sharanova, Svetlana N. ;

Tramontano, Alfonso ;

Friboulet, Alain ;

Boyko, Alexey N. ;

Ponomarenko, Natalia A. ;

Tikunova, Nina V. .

FASEB JOURNAL, 2011, 25 (12) :4211-4221

[22] Environmental risk factors in multiple sclerosis [J].

Pugliatti, M. ;

Harbo, H. F. ;

Holmoy, T. ;

Kampman, M. T. ;

Myhr, K. -M. ;

Riise, T. ;

Wolfson, C. .

ACTA NEUROLOGICA SCANDINAVICA, 2008, 117 :34-40

[23] Environmental risk factors in multiple sclerosis [J].

Lauer, Klaus .

EXPERT REVIEW OF NEUROTHERAPEUTICS, 2010, 10 (03) :421-440

[24] Risk Factors from Pregnancy to Adulthood in Multiple Sclerosis Outcome [J].

Gonzalez-Madrid, Enrique ;

Rangel-Ramirez, Ma. Andreina ;

Mendoza-Leon, Maria Jose ;

Alvarez-Mardones, Oscar ;

Gonzalez, Pablo A. ;

Kalergis, Alexis M. ;

Opazo, Ma. Cecilia ;

Riedel, Claudia A. .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (13)

[25] Epstein-Barr virus neutralizing antibody levels and risk of multiple sclerosis [J].

Simon, Kelly Claire ;

O'Reilly, Eilis J. ;

Munger, Kassandra L. ;

Finerty, Susan ;

Morgan, Andrew J. ;

Ascherio, Alberto .

MULTIPLE SCLEROSIS JOURNAL, 2012, 18 (08) :1185-1187

[26] The Interaction between Viral and Environmental Risk Factors in the Pathogenesis of Multiple Sclerosis [J].

Tarlinton, Rachael Eugenie ;

Khaibullin, Timur ;

Granatov, Evgenii ;

Martynova, Ekaterina ;

Rizvanov, Albert ;

Khaiboullina, Svetlana .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (02)

[27] Increased anti-EBV VCA IgG antibody levels are associated with need for surgery in patients developing upper respiratory tract complications [J].

Arslan, Hande ;

Candar, Tuba ;

Vural, Ozge .

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, 2018, 111 :84-88

[28] Onset Symptom Clusters in Multiple Sclerosis: Characteristics, Comorbidities, and Risk Factors [J].

Ajdacic-Gross, Vladeta ;

Steinemann, Nina ;

Horvath, Gabor ;

Rodgers, Stephanie ;

Kaufmann, Marco ;

Xu, Yanhua ;

Kamm, Christian P. ;

Kesselring, Jurg ;

Manjaly, Zina-Mary ;

Zecca, Chiara ;

Calabrese, Pasquale ;

Puhan, Milo A. ;

von Wyl, Viktor .

FRONTIERS IN NEUROLOGY, 2021, 12

[29] Interactions between genetic, lifestyle and environmental risk factors for multiple sclerosis [J].

Olsson, Tomas ;

Barcellos, Lisa F. ;

Alfredsson, Lars .

NATURE REVIEWS NEUROLOGY, 2017, 13 (01) :25-36

[30] Risk Factors Associated with the Onset of Relapsing-Remitting and Primary Progressive Multiple Sclerosis: A Systematic Review [J].

McKay, Kyla A. ;

Kwan, Vivian ;

Duggan, Thomas ;

Tremlett, Helen .

BIOMED RESEARCH INTERNATIONAL, 2015, 2015

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