A comprehensive study on antidiabetic and antibacterial activities of ZnO nanoparticles biosynthesized using Silybum marianum L seed extract

被引:111
作者
Arvanag, Farid Mohammadi [1 ]
Bayrami, Abolfazl [1 ]
Habibi-Yangjeh, Aziz [2 ]
Pouran, Shima Rahim [3 ,4 ]
机构
[1] Univ Mohaghegh Ardabili, Dept Biol, Fac Sci, POB 179, Ardebil, Iran
[2] Univ Mohaghegh Ardabili, Dept Chem, Fac Sci, POB 179, Ardebil, Iran
[3] Univ Malaya, Dept Mech Engn, Ctr Adv Mfg & Mat Proc, Fac Engn, Kuala Lumpur 50603, Malaysia
[4] Ardabil Univ Med Sci, Ardebil, Iran
来源
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2019年 / 97卷
关键词
Diabetes mellitus; Grain-negative bacteria; Green synthesis; Insulin; Lipid profile; Nanomedicine; ZINC-OXIDE NANOPARTICLES; SILVER NANOPARTICLES; DIABETES-MELLITUS; AQUEOUS EXTRACT; GREEN SYNTHESIS; LEAF EXTRACT; IN-VITRO; SILYMARIN; SEPARATION; APOPTOSIS;
D O I
10.1016/j.msec.2018.12.058
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
Green synthesis of ZnO nanoparticles (NPs) using the plants' extract and their potential application have driven a tremendous interest in recent years. This study reports a green microwave-assisted method for synthesis of ZnO NPs using Silybum marianum L. seed extract. Characteristics of the as-prepared sample was explored in terms of crystalline phase, morphology, composition, surface area, optical, and thermal properties. The particles of the biosynthesized sample (ZnO/extract) had smaller sizes than the chemically produced one (ZnO). The existence of biomolecules from Silybum marianum L. seed extract linked to the ZnO/extract sample was approved by various analyses. The ZnO/extract sample was used for treating alloxan-induced diabetic rats and its efficiency was compared with ZnO, extract, and insulin treatments. For this purpose, the levels of blood glucose, insulin, total cholesterol, total triglyceride, and high-density lipoprotein were measured before and after treating with the studied treatment agents and compared with each other. Moreover, the antibacterial activities of both ZnO samples were investigated against E. coli to assess their potential antibacterial application. From the results, ZnO/extract NPs represented an outstanding performance in overcoming the diabetic disorders and good antibacterial activity against the studied bacteria.
引用
收藏
页码:397 / 405
页数:9
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