Near-infrared aza-BODIPY fluorescent probe for selective Cu2+ detection and its potential in living cell imaging

被引：34

作者：

Tachapermpon, Yordkhuan ^{[1
]}

Thavornpradit, Sopida ^{[1
]}

Charoenpanich, Adisri ^{[2
]}

Sirirak, Jitnapa ^{[1
]}

Burgess, Kevin ^{[3
]}

Wanichacheva, Nantanit ^{[1
]}

机构：

[1] Silpakorn Univ, Fac Sci, Dept Chem, Amphoe Muang 73000, Nakhon Pathom, Thailand

[2] Silpakorn Univ, Fac Sci, Dept Biol, Amphoe Muang 73000, Nakhon Pathom, Thailand

[3] Texas A&M Univ, Dept Chem, Box 30012, College Stn, TX 77842 USA

来源：

DALTON TRANSACTIONS | 2017年 / 46卷 / 46期

关键词：

STRIPPING VOLTAMMETRY; COPPER-ION; ON-OFF; SENSOR; CHEMOSENSOR; DYES; COORDINATION; DERIVATIVES; CU(II); CATION;

D O I：

10.1039/c7dt03481d

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A near-infrared (NIR) fluorescent sensor 1 composed of an aza-boron-dipyrromethene (aza-BODIPY) core covalently bound to two di-2-picolylamine moieties was conceived for Cu2+ detection in aqueous solutions. Spectroscopic properties and binding abilities with several metal ions were investigated in phosphate buffered saline (pH 7.4): acetonitrile (95 : 5 v/v) with Triton X-100 via fluorometric titrations. The fluorescence of sensor 1 was quenched selectively by cupric ions in the presence of alkali-and transition-metal-ions. A detection limit of 13 ppb was measured for this system, and this is significantly lower than permissible levels of Cu2+ in drinking water according to the guidelines described by the U.S. Environmental Protection Agency (EPA) and by the World Health Organization (WHO). Application of the sensor in detecting Cu2+ in HepG2 cells was demonstrated.

引用

页码：16251 / 16256

页数：6

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