Chemiluminescent Nanomicelles for Imaging Hydrogen Peroxide and Self-Therapy in Photodynamic Therapy

被引：61

作者：

Chen, Rui ^{[3
,4
]}

Zhang, Luzhong ^{[3
,4
]}

Gao, Jian ^{[1
,2
]}

Wu, Wei ^{[3
,4
]}

Hu, Yong ^{[1
,2
]}

Jiang, Xiqun ^{[3
,4
]}

机构：

[1] Nanjing Univ, Natl Lab Solid State Microstruct, Nanjing 210093, Peoples R China

[2] Nanjing Univ, Dept Mat Sci & Engn, Nanjing 210093, Peoples R China

[3] Nanjing Univ, Lab Mesoscop Chem, Coll Chem & Chem Engn, Nanjing 210093, Peoples R China

[4] Nanjing Univ, Dept Polymer Sci & Engn, Coll Chem & Chem Engn, Nanjing 210093, Peoples R China

来源：

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY | 2011年

关键词：

PEROXYOXALATE CHEMILUMINESCENCE; MICELLES; DELIVERY; NANOPARTICLES; SOLUBILIZATION; OXYGEN; STEP; DRUG;

D O I：

10.1155/2011/679492

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Hydrogen peroxide is a signal molecule of the tumor, and its overproduction makes a higher concentration in tumor tissue compared to normal tissue. Based on the fact that peroxalates can make chemiluminescence with a high efficiency in the presence of hydrogen peroxide, we developed nanomicelles composed of peroxalate ester oligomers and fluorescent dyes, called peroxalate nanomicelles (POMs), which could image hydrogen peroxide with high sensitivity and stability. The potential application of the POMs in photodynamic therapy (PDT) for cancer was also investigated. It was found that the PDT-drug-loaded POMs were sensitive to hydrogen peroxide, and the PDT drug could be stimulated by the chemiluminescence from the reaction between POMs and hydrogen peroxide, which carried on a self-therapy of the tumor without the additional laser light resource.

引用

页数：9

共 31 条

[11] Intraparticle energy transfer and fluorescence photoconversion in nanoparticles: An optical highlighter nanoprobe for two-photon bioimaging [J].