Antinociceptive effect of Lafoensia pacari A. St.-Hil. independent of anti-inflammatory activity of ellagic acid

被引：18

作者：

Mariano Nascimento, Marcus Vinicius ^{[1
]}

Galdino, Pablinny Moreira ^{[1
]}

Florentino, Iziara Ferreira ^{[1
]}

Sampaio, Bruno Leite ^{[3
]}

Vanderlinde, Frederico Argollo ^{[2
]}

de Paula, Jose Realino ^{[3
]}

Costa, Elson Alves ^{[1
]}

机构：

[1] Univ Fed Goias, Inst Ciencias Biol 2, Lab Farmacol Prod Nat, BR-74001970 Goiania, Go, Brazil

[2] Univ Fed Rural Rio de Janeiro, Dept Ciencias Fisiol, Seropedica, RJ, Brazil

[3] Univ Fed Goias, Fac Farm, Lab Pesquisa Prod Nat, BR-74001970 Goiania, Go, Brazil

来源：

JOURNAL OF NATURAL MEDICINES | 2011年 / 65卷 / 3-4期

关键词：

Medicinal plants; Analgesic activity; Bioactivity-guided fractionation; Neurogenic pain; Formalin test; FORMALIN TEST; ACETIC-ACID; NOCICEPTIVE RESPONSE; EXTRACT; PAIN; MICE; INVOLVEMENT; ANALGESICS; ANTAGONISM; EXPRESSION;

D O I：

10.1007/s11418-011-0517-y

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This study was performed to determine the antinociceptive and anti-inflammatory activities of ethanolic extract of Lafoensia pacari A. St.-Hil. (PEtExt) stem bark and its fractions using various animal models such as acetic acid-induced abdominal writhing, formalin-induced pain and croton oil-induced ear edema tests. The PEtExt inhibited the acetic acid-induced abdominal writhing, reduced the pain reaction time on both phases of the formalin test and decreased the edema in a dose-dependent manner. Pre-treatment with naloxone did not reverse the antinociceptive effect. Only the ethyl acetate fraction showed antinociceptive and anti-inflammatory effects. Our results also showed that this extract contains compounds with analgesic action independent of anti-inflammatory activity.

引用

页码：448 / 454

页数：7