Antinociceptive effect of Lafoensia pacari A. St.-Hil. independent of anti-inflammatory activity of ellagic acid

被引：18
|
作者：
Mariano Nascimento, Marcus Vinicius [1 ]
Galdino, Pablinny Moreira [1 ]
Florentino, Iziara Ferreira [1 ]
Sampaio, Bruno Leite [3 ]
Vanderlinde, Frederico Argollo [2 ]
de Paula, Jose Realino [3 ]
Costa, Elson Alves [1 ]
机构：
[1] Univ Fed Goias, Inst Ciencias Biol 2, Lab Farmacol Prod Nat, BR-74001970 Goiania, Go, Brazil
[2] Univ Fed Rural Rio de Janeiro, Dept Ciencias Fisiol, Seropedica, RJ, Brazil
[3] Univ Fed Goias, Fac Farm, Lab Pesquisa Prod Nat, BR-74001970 Goiania, Go, Brazil
来源：
JOURNAL OF NATURAL MEDICINES | 2011年 / 65卷 / 3-4期
关键词：
Medicinal plants; Analgesic activity; Bioactivity-guided fractionation; Neurogenic pain; Formalin test; FORMALIN TEST; ACETIC-ACID; NOCICEPTIVE RESPONSE; EXTRACT; PAIN; MICE; INVOLVEMENT; ANALGESICS; ANTAGONISM; EXPRESSION;
D O I：
10.1007/s11418-011-0517-y
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
This study was performed to determine the antinociceptive and anti-inflammatory activities of ethanolic extract of Lafoensia pacari A. St.-Hil. (PEtExt) stem bark and its fractions using various animal models such as acetic acid-induced abdominal writhing, formalin-induced pain and croton oil-induced ear edema tests. The PEtExt inhibited the acetic acid-induced abdominal writhing, reduced the pain reaction time on both phases of the formalin test and decreased the edema in a dose-dependent manner. Pre-treatment with naloxone did not reverse the antinociceptive effect. Only the ethyl acetate fraction showed antinociceptive and anti-inflammatory effects. Our results also showed that this extract contains compounds with analgesic action independent of anti-inflammatory activity.
引用
收藏
页码：448 / 454
页数：7
相关论文
共 29 条
  • [21] Antinociceptive local activity of 4-allyl-1-hydroxy-2-methoxybenzene (eugenol) by the formalin test: an anti-inflammatory effect
    Elizabeth Lugo-Lugo, Daniela
    de Jesus Pozos-Guillen, Amaury
    Ramon Zapata-Morales, Juan
    Rodriguez-Chong, Antonio
    de Jesus Rangel-Lopez, Azahel
    Zenaida Saavedra-Leos, Maria
    Vertiz-Hernandez, Antonio
    BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2019, 55
  • [22] Formulated chitosan-sodium tripolyphosphate nanoparticles for co-encapsulation of ellagic acid and anti-inflammatory peptide: characterization, stability and anti-inflammatory activity
    Xiong, Yu
    Feng, Yan-Xia
    Chang, Min
    Wang, Qian
    Yin, Sheng-Nan
    Jian, Liu-Yu
    Ren, Di-Feng
    JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 2023, 103 (07) : 3447 - 3456
  • [23] In-vivo antinociceptive, anti-inflammatory and antipyretic activity of pistagremic acid isolated from Pistacia integerrima
    Rauf, Abdur
    Uddin, Ghias
    Siddiqui, Bina S.
    Khan, Ajmal
    Khan, Haroon
    Arfan, Mohammad
    Muhammad, Naveed
    Wadood, Abdul
    PHYTOMEDICINE, 2014, 21 (12) : 1509 - 1515
  • [24] A study of the mechanisms underlying the anti-inflammatory effect of ellagic acid in carrageenan-induced paw edema in rats
    Mansouri, Mohammad Taghi
    Hemmati, Ali Asghar
    Naghizadeh, Bahareh
    Mard, Seyyed Ali
    Rezaie, Anahita
    Ghorbanzadeh, Behnam
    INDIAN JOURNAL OF PHARMACOLOGY, 2015, 47 (03) : 292 - 298
  • [25] Antinociceptive and anti-inflammatory effect of Passiflora edulis leaves extract in acetic acid-induced and oedema in vivo
    Sandhiutami, Ni Made Dwi
    Desmiaty, Yesi
    Fahleni
    Fakhran, Mohammad Haidi
    PHARMACY EDUCATION, 2024, 24 (02): : 78 - 85
  • [26] Anti-Inflammatory Activity of the Combination of Nobiletin and Docosahexaenoic Acid in Lipopolysaccharide-Stimulated RAW 264.7 Cells: A Potential Synergistic Anti-Inflammatory Effect
    Nishi, Kosuke
    Nakatani, Yuki
    Ishida, Momoko
    Kadota, Ayumu
    Sugahara, Takuya
    NUTRIENTS, 2024, 16 (13)
  • [27] Anti-inflammatory and Anti-apoptotic Effect of Valproic Acid and Doxycycline Independent from MMP Inhibition in Early Radiation Damage
    Hosgorler, Ferda
    Keles, Didem
    Tanriverdi-Akhisaroglu, Serpil
    Inanc, Seniz
    Akhisaroglu, Mustafa
    Cankurt, Ulker
    Aydogdu, Zekiye
    Ucar, Ahmet Deniz
    Cetinayak, Oguz
    Oktay, Gulgun
    Arda, Sevil Gonenc
    BALKAN MEDICAL JOURNAL, 2016, 33 (05) : 488 - 495
  • [28] Fatty Acid Composition, Antioxidant, and in vitro Anti-inflammatory Activity of Five Cold-Pressed Prunus Seed Oils, and Their Anti-biofilm Effect Against Pathogenic Bacteria
    Fratianni, Florinda
    D'Acierno, Antonio
    Ombra, Maria Neve
    Amato, Giuseppe
    De Feo, Vincenzo
    Ayala-Zavala, Juan Fernando
    Coppola, Raffaele
    Nazzaro, Filomena
    FRONTIERS IN NUTRITION, 2021, 8
  • [29] Intestinal anti-inflammatory activity of xique-xique (Pilosocereus gounellei A. Weber ex K. Schum. Bly. Ex Rowl) juice on acetic acid-induced colitis in rats
    de Assis, Paloma Oliveira Antonino
    Guerra, Gerlane Coelho Bernardo
    Araujo, Daline Fernandes de Souza
    de Andrade, Leylliane de Fatima Leal Interaminense
    de Araujo, Aurigena Antunes
    de Araujo Junior, Raimundo Fernandes
    de Carvalho, Thais Gomes
    de Souza, Maria de Fatima Vanderlei
    Borges, Graciele da Silva Campelo
    Lima, Marcos dos Santos
    Rolim, Fernanda Rodrigues Leite
    Rodrigues, Raphaela Araujo Veloso
    Queiroga, Rita de Cassia Ramos do Egypto
    FOOD & FUNCTION, 2019, 10 (11) : 7275 - 7290
123