Why do seizures impair consciousness and how can we reverse this?

被引:11
作者
Lambert, Isabelle [1 ]
Bartolomei, Fabrice [2 ]
机构
[1] Aix Marseille Univ, INSERM, INS, Marseille, France
[2] Timone Hosp, APHM, Epileptol Dept, Marseille, France
关键词
awareness; brain network; classification; consciousness; epilepsy; neurostimulation; NERVE-STIMULATION VNS; ELECTRICAL-STIMULATION; GLOBAL WORKSPACE; EPILEPSY; BRAIN; RESPONSIVENESS; THALAMUS; NUCLEUS; EEG;
D O I
10.1097/WCO.0000000000000794
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Purpose of review Consciousness disorders occurring during seizures are a major source of disability in people with epilepsy. The purpose of this review is to show recent developments in the assessment and understanding of consciousness disorders in epilepsy. Recent findings The most frequent alterations in consciousness are alterations in the level of awareness. They are linked to disruptions on a large-scale network of fronto-parietal associative systems in different forms of focal seizures or in absences. Different theories account for these alterations. Although there is no specific treatment for 'consciousness,' high expectations are placed on brain stimulation techniques, which need to be better defined in the future in terms of targets and parameters.
引用
收藏
页码:173 / 178
页数:6
相关论文
共 44 条
  • [1] Mechanisms of decreased cholinergic arousal in focal seizures: In vivo whole-cell recordings from the pedunculopontine tegmental nucleus
    Andrews, John P.
    Yue, Zongwei
    Ryu, Jun Hwan
    Neske, Garrett
    McCormick, David A.
    Blumenfeld, Hal
    [J]. EXPERIMENTAL NEUROLOGY, 2019, 314 : 74 - 81
  • [2] [Anonymous], 1981, Epilepsia, V22, P489
  • [3] Impaired consciousness during temporal lobe seizures is related to increased long-distance corticalsubcortical synchronization
    Arthuis, Marie
    Valton, Luc
    Regis, Jean
    Chauvel, Patrick
    Wendling, Fabrice
    Naccache, Lionel
    Bernard, Christophe
    Bartolomei, Fabrice
    [J]. BRAIN, 2009, 132 : 2091 - 2101
  • [4] Cortical stimulation study of the role of rhinal cortex in deja vu and reminiscence of memories
    Bartolomei, F
    Barbeau, E
    Gavaret, M
    Guye, M
    McGonigal, A
    Régis, J
    Chauvel, P
    [J]. NEUROLOGY, 2004, 63 (05) : 858 - 864
  • [5] The role of the dorsal anterior insula in ecstatic sensation revealed by direct electrical brain stimulation
    Bartolomei, F.
    Lagarde, S.
    Scavarda, D.
    Carron, R.
    Benar, C. G.
    Picard, F.
    [J]. BRAIN STIMULATION, 2019, 12 (05) : 1121 - 1126
  • [6] Defining epileptogenic networks: Contribution of SEEG and signal analysis
    Bartolomei, Fabrice
    Lagarde, Stanislas
    Wendling, Fabrice
    McGonigal, Aileen
    Jirsa, Viktor
    Guye, Maxime
    Benar, Christian
    [J]. EPILEPSIA, 2017, 58 (07) : 1131 - 1147
  • [7] How does vagal nerve stimulation (VNS) change EEG brain functional connectivity?
    Bartolomei, Fabrice
    Bonini, Francesca
    Vidal, Elsa
    Trebuchon, Agnes
    Lagarde, Stanislas
    Lambert, Isabelle
    McGonigal, Aileen
    Scavarda, Didier
    Carron, Romain
    Benar, Christian G.
    [J]. EPILEPSY RESEARCH, 2016, 126 : 141 - 146
  • [8] Alteration of consciousness in focal epilepsy: The global workspace alteration theory
    Bartolomei, Fabrice
    McGonigal, Aileen
    Naccache, Lionel
    [J]. EPILEPSY & BEHAVIOR, 2014, 30 : 17 - 23
  • [9] Prospective assessment of ictal behavior using the revised Responsiveness in Epilepsy Scale (RES-II)
    Bauerschmidt, Andrew
    Koshkelashvili, Nika
    Ezeani, Celestine C.
    Yoo, Ji Yeoun
    Zhang, Yan
    Manganas, Louis N.
    Kapadia, Kailash
    Palenzuela, Deanna
    Schmidt, Christian C.
    Lief, Regina
    Kiely, Bridget T.
    Choezom, Tenzin
    McClurkin, Michael
    Shorten, Andrew
    Detyniecki, Kamil
    Hirsch, Lawrence J.
    Giacino, Joseph T.
    Blumenfeld, Hal
    [J]. EPILEPSY & BEHAVIOR, 2013, 26 (01) : 25 - 28
  • [10] Bensaid S, 2019, COALIA COMPUTATIONAL, P575043