Purpose of Review The review provides an update on the diagnosis, pathogenesis, and treatment of cutaneous lupus erythematosus (CLE). Recent Findings Diagnostic challenges exist in better defining CLE as an independent disease distinct from systemic lupus erythematosus with cutaneous features and further classifying CLE based on clinical, histological, and laboratory features. Recent mechanistic studies revealed more genetic variations, environmental triggers, and immunologic dysfunctions that are associated with CLE. Drug induction specifically has emerged as one of the most important triggers for CLE. Treatment options include topical agents and systemic therapies, including newer biologics such as belimumab, rituximab, ustekinumab, anifrolumab, and BIIB059 that have shown good clinical efficacy in trials. CLE is a group of complex and heterogenous diseases. Future studies are warranted to better define CLE within the spectrum of lupus erythematosus. Better insight into the pathogenesis of CLE could facilitate the design of more targeted therapies.
机构:
Univ Cape Town, Groote Schuur Hosp, Dept Med, ZA-7925 Cape Town, Western Cape, South AfricaUniv Cape Town, Groote Schuur Hosp, Dept Med, ZA-7925 Cape Town, Western Cape, South Africa
Jessop, Sue
Whitelaw, David A.
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Univ Stellenbosch, Div Rheumatol, Dept Med, Cape Town, South AfricaUniv Cape Town, Groote Schuur Hosp, Dept Med, ZA-7925 Cape Town, Western Cape, South Africa
Whitelaw, David A.
Grainge, Matthew J.
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Sch Med, Div Epidemiol & Publ Hlth, Nottingham, EnglandUniv Cape Town, Groote Schuur Hosp, Dept Med, ZA-7925 Cape Town, Western Cape, South Africa
Grainge, Matthew J.
Jayasekera, Prativa
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Broadgreen Hosp, Dept Dermatol, Liverpool, Merseyside, EnglandUniv Cape Town, Groote Schuur Hosp, Dept Med, ZA-7925 Cape Town, Western Cape, South Africa
Jayasekera, Prativa
COCHRANE DATABASE OF SYSTEMATIC REVIEWS,
2017,
(05):
机构:
Corporal Michael J Crescenz VA Med Ctr, Dept Dermatol, Philadelphia, PA 19104 USA
Univ Penn, Dept Dermatol, Perelman Sch Med, Philadelphia, PA 19104 USACorporal Michael J Crescenz VA Med Ctr, Dept Dermatol, Philadelphia, PA 19104 USA
Yan, Daisy
Borucki, Robert
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机构:
Corporal Michael J Crescenz VA Med Ctr, Dept Dermatol, Philadelphia, PA 19104 USA
Univ Penn, Dept Dermatol, Perelman Sch Med, Philadelphia, PA 19104 USACorporal Michael J Crescenz VA Med Ctr, Dept Dermatol, Philadelphia, PA 19104 USA
Borucki, Robert
Sontheimer, Richard D.
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机构:
Univ Utah, Sch Med, Dept Dermatol, Salt Lake City, UT USACorporal Michael J Crescenz VA Med Ctr, Dept Dermatol, Philadelphia, PA 19104 USA
Sontheimer, Richard D.
Werth, Victoria P.
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机构:
Corporal Michael J Crescenz VA Med Ctr, Dept Dermatol, Philadelphia, PA 19104 USA
Univ Penn, Dept Dermatol, Perelman Sch Med, Philadelphia, PA 19104 USACorporal Michael J Crescenz VA Med Ctr, Dept Dermatol, Philadelphia, PA 19104 USA
机构:
Corporal Michael J Crescenz Vet Affairs Med Ctr P, Philadelphia, PA USA
Univ Penn, Perelman Ctr Adv Med, Perelman Sch Med, Dept Dermatol, Suite 1-330A,3400 Civ Ctr Blvd, Philadelphia, PA 19104 USACorporal Michael J Crescenz Vet Affairs Med Ctr P, Philadelphia, PA USA
Hejazi, Emily Z.
Werth, Victoria P.
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机构:
Corporal Michael J Crescenz Vet Affairs Med Ctr P, Philadelphia, PA USA
Univ Penn, Perelman Ctr Adv Med, Perelman Sch Med, Dept Dermatol, Suite 1-330A,3400 Civ Ctr Blvd, Philadelphia, PA 19104 USACorporal Michael J Crescenz Vet Affairs Med Ctr P, Philadelphia, PA USA
机构:
Sorbonne Univ, Hop Tenon, AP HP, Fac Med,Serv Dermatol & Allergol, 4 Rue Chine, F-75020 Paris 20, FranceSorbonne Univ, Hop Tenon, AP HP, Fac Med,Serv Dermatol & Allergol, 4 Rue Chine, F-75020 Paris 20, France
Chasset, Francois
Frances, Camille
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Sorbonne Univ, Hop Tenon, AP HP, Fac Med,Serv Dermatol & Allergol, 4 Rue Chine, F-75020 Paris 20, FranceSorbonne Univ, Hop Tenon, AP HP, Fac Med,Serv Dermatol & Allergol, 4 Rue Chine, F-75020 Paris 20, France