Taking the Tube: From Normal Fallopian Tube Epithelium to Ovarian High-grade Serous Carcinoma

被引：9
作者：
Tone, Alicia A. [1 ]
机构：
[1] Princess Margaret Canc Ctr, Div Gynecol Oncol, 700 Univ Ave,2nd Floor, Toronto, ON, Canada
来源：
CLINICAL OBSTETRICS AND GYNECOLOGY | 2017年 / 60卷 / 04期
关键词：
fallopian tube; high-grade serous carcinoma; precursor lesions; molecular alterations; follicular fluid; retrograde menstruation; BRCA-MUTATION CARRIERS; INCESSANT MENSTRUATION HYPOTHESIS; PELVIC-INFLAMMATORY-DISEASE; ORAL-CONTRACEPTIVE USE; INTRAEPITHELIAL CARCINOMA; FOLLICULAR-FLUID; OXIDATIVE STRESS; RISK-FACTORS; CANCER RISK; CANDIDATE PRECURSOR;
D O I：
10.1097/GRF.0000000000000313
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Detailed pathologic studies over the past decade suggest a distal fallopian tube origin for the majority of "ovarian'' high-grade serous carcinomas (HGSC). This review will summarize molecular alterations observed in tubal precursors for HGSC, namely p53 signatures and serous tubal intraepithelial carcinomas, and in nonmalignant fallopian tube epithelial cells obtained from women at increased genetic risk for HGSC. Recent experiments investigating the impact of follicular fluid exposure and retrograde menstruation on tumor development in the fallopian tube will also be discussed. These data will be reconciled with traditional ovarian cancer risk factors related to reproductive history.
引用
收藏
页码：697 / 710
页数：14
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