Taking the Tube: From Normal Fallopian Tube Epithelium to Ovarian High-grade Serous Carcinoma

被引：9
作者：
Tone, Alicia A. [1 ]
机构：
[1] Princess Margaret Canc Ctr, Div Gynecol Oncol, 700 Univ Ave,2nd Floor, Toronto, ON, Canada
来源：
CLINICAL OBSTETRICS AND GYNECOLOGY | 2017年 / 60卷 / 04期
关键词：
fallopian tube; high-grade serous carcinoma; precursor lesions; molecular alterations; follicular fluid; retrograde menstruation; BRCA-MUTATION CARRIERS; INCESSANT MENSTRUATION HYPOTHESIS; PELVIC-INFLAMMATORY-DISEASE; ORAL-CONTRACEPTIVE USE; INTRAEPITHELIAL CARCINOMA; FOLLICULAR-FLUID; OXIDATIVE STRESS; RISK-FACTORS; CANCER RISK; CANDIDATE PRECURSOR;
D O I：
10.1097/GRF.0000000000000313
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Detailed pathologic studies over the past decade suggest a distal fallopian tube origin for the majority of "ovarian'' high-grade serous carcinomas (HGSC). This review will summarize molecular alterations observed in tubal precursors for HGSC, namely p53 signatures and serous tubal intraepithelial carcinomas, and in nonmalignant fallopian tube epithelial cells obtained from women at increased genetic risk for HGSC. Recent experiments investigating the impact of follicular fluid exposure and retrograde menstruation on tumor development in the fallopian tube will also be discussed. These data will be reconciled with traditional ovarian cancer risk factors related to reproductive history.
引用
收藏
页码：697 / 710
页数：14
相关论文
共 50 条
  • [31] Natural history of ovarian high-grade serous carcinoma from time effects of ovulation inhibition and progesterone clearance of p53-defective lesions
    Wu, Na-Yi Yuan
    Fang, Chao
    Huang, Hsuan-Shun
    Wang, Jing
    Chu, Tang-Yuan
    MODERN PATHOLOGY, 2020, 33 (01) : 29 - 37
  • [32] A 3-Tier Chemotherapy Response Score for Ovarian/Fallopian Tube/Peritoneal High-grade Serous Carcinoma Is it Clinically Relevant?
    Lawson, Barrett C.
    Euscher, Elizabeth D.
    Bassett, Roland L.
    Liu, Jinsong
    Ramalingam, Preetha
    Zhong, YanPing
    Fleming, Nicole D.
    Malpica, Anais
    AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2020, 44 (02) : 206 - 213
  • [33] Fallopian tube initiation of high grade serous ovarian cancer and ovarian metastasis: Mechanisms and therapeutic implications
    Bergsten, Tova M.
    Burdette, Joanna E.
    Dean, Matthew
    CANCER LETTERS, 2020, 476 : 152 - 160
  • [34] The clinical impact of serous tubal intraepithelial carcinoma on outcomes of patients with high-grade serous carcinoma of the ovary, fallopian tube, and peritoneum
    Toptas, Tayfun
    Pestereli, Elif
    Simsek, Tayup
    Bozkurt, Selen
    Erdogan, Gulgun
    Karaveli, Seyda
    JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, 2018, 14 (03) : 587 - 592
  • [35] TP53 variant allele frequency correlates with the chemotherapy response score in ovarian/fallopian tube/peritoneal high-grade serous carcinoma
    Lawson, Barrett C.
    Yang, Richard K.
    Euscher, Elizabeth D.
    Ramalingam, Preetha
    Malpica, Anais
    HUMAN PATHOLOGY, 2021, 115 : 76 - 83
  • [36] Characterization of Primary Cilia in Normal Fallopian Tube Epithelium and Serous Tubal Intraepithelial Carcinoma
    Abdelhamed, Zakia A.
    Ryan, Thomas A.
    Fuller, Martin
    Coulson-Gilmer, Camilla
    Abdelmottaleb, Dina I.
    Wang, Tian-Li
    Kaun, Jen-Chun
    Wang, Peiyi
    Hutson, Richard
    Wilkinson, Nafisa
    Bell, Sandra M.
    Johnson, Colin A.
    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2018, 28 (08) : 1535 - 1544
  • [37] Fallopian tube secreted protein affects ovarian metabolites in high grade serous ovarian cancer
    Bergsten, Tova M.
    Levy, Sarah E.
    Zink, Katherine E.
    Lusk, Hannah J.
    Pergande, Melissa R.
    Cologna, Stephanie M.
    Burdette, Joanna E.
    Sanchez, Laura M.
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022, 10
  • [38] Mechanisms of High-Grade Serous Carcinogenesis in the Fallopian Tube and Ovary: Current Hypotheses, Etiologic Factors, and Molecular Alterations
    Otsuka, Isao
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (09)
  • [39] The Fallopian Tube as the Origin of High Grade Serous Ovarian Cancer: Review of a Paradigm Shift
    Reade, Clare J.
    Mcvey, Ruaidhri M.
    Tone, Alicia A.
    Finlayson, Sarah J.
    McAlpine, Jessica N.
    Fung-Kee-Fung, Michael
    Ferguson, Sarah E.
    JOURNAL OF OBSTETRICS AND GYNAECOLOGY CANADA, 2014, 36 (02) : 133 - 140
  • [40] Loss of PAX8 in high-grade serous ovarian cancer reduces cell survival despite unique modes of action in the fallopian tube and ovarian surface epithelium
    Rodgers, Laura H.
    hAimhire, Eoghainin O.
    Young, Alexandria N.
    Burdette, Joanna E.
    ONCOTARGET, 2016, 7 (22) : 32785 - 32795
12345