Sensory Circuit Remodeling and Movement Recovery After Spinal Cord Injury

被引：5
|
作者：
Moreno-Lopez, Yunuen [1 ]
Hollis, Edmund R. [1 ,2 ]
机构：
[1] Burke Neurol Inst, White Plains, NY 10605 USA
[2] Weill Cornell Med, Feil Family Brain & Mind Res Inst, New York, NY 10021 USA
来源：
FRONTIERS IN NEUROSCIENCE | 2021年 / 15卷
基金：
美国国家卫生研究院;
关键词：
spinal cord injury; corticospinal; corticocortical; movement recovery; rehabilitation; MOTOR CORTEX; SOMATOSENSORY CORTEX; INTRACORTICAL CONNECTIONS; PROPRIOCEPTIVE FEEDBACK; FUNCTIONAL RECOVERY; LOCOMOTOR RECOVERY; DORSAL COLUMNS; REORGANIZATION; NEURONS; REACTIVATION;
D O I：
10.3389/fnins.2021.787690
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Restoring sensory circuit function after spinal cord injury (SCI) is essential for recovery of movement, yet current interventions predominantly target motor pathways. Integrated cortical sensorimotor networks, disrupted by SCI, are critical for perceiving, shaping, and executing movement. Corticocortical connections between primary sensory (S1) and motor (M1) cortices are critical loci of functional plasticity in response to learning and injury. Following SCI, in the motor cortex, corticocortical circuits undergo dynamic remodeling; however, it remains unknown how rehabilitation shapes the plasticity of S1-M1 networks or how these changes may impact recovery of movement.
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收藏
页数：5
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