A flow-based transition-metal-catalysed hydrogenolysis strategy to facilitate peptide side-chain deprotection

被引：2
|
作者：
Menti-Platten, Maria [1 ,4 ]
Aldrich-Wright, Janice R. [1 ,2 ]
Gordon, Christopher P. [1 ,2 ,3 ]
机构：
[1] Western Sydney Univ, Sch Sci, Locked Bag 1797, Penrith, Australia
[2] Nanoscale Org & Dynam Grp, Locked Bag 1797, Penrith, Australia
[3] Western Sydney Univ, Sch Med, Mol Med Res Grp, Narellan Rd & Gilchrist Dr, Camphelltown, NSW 2560, Australia
[4] Univ Wollongong, Sch Chem & Mol Biosci, Wollongong, NSW 2522, Australia
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2021年 / 20卷 / 01期
关键词：
BENZYL PROTECTIVE GROUP; O-BENZYL; HYDROGENATION; REMOVAL; SOLVENT; HYDRODECHLORINATION; PROTOCOL; ACCESS;
D O I：
10.1039/d1ob02179f
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Orthogonal deprotection methodologies are an invaluable tool for the construction of site-specially modified peptides. Here, we report a facile 10% Pd/CaCO3-based procedure to selectively mediate N beta-side-chain Cbz-lysis from extended peptide sequences in the presence of trityl and t-Butyl protecting groups.
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页码：106 / 112
页数：7
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