Circulating short-chain fatty acids in type 2 diabetic patients and overweight/obese individuals

被引：6

作者：

Salamone, Dominic ^{[1
]}

Costabile, Giuseppina ^{[1
,2
]}

Corrado, Alessandra ^{[1
]}

Della Pepa, Giuseppe ^{[1
]}

Vitale, Marilena ^{[1
]}

Giacco, Rosalba ^{[3
]}

Luongo, Delia ^{[4
]}

Testa, Roberta ^{[1
]}

Rivellese, Angela Albarosa ^{[1
,2
]}

Annuzzi, Giovanni ^{[1
,2
]}

Bozzetto, Lutgarda ^{[1
,2
]}

机构：

[1] Univ Naples Federico II, Dept Clin Med & Surg, Sergio Pansini 5, I-80131 Naples, Italy

[2] Univ Naples Federico II, Task Force Microbiome Studies, Naples, Italy

[3] CNR, Inst Food Sci, I-83100 Avellino, Italy

[4] CNR, Inst Biostruct & Bioimaging, I-80100 Naples, Italy

来源：

ACTA DIABETOLOGICA | 2022年 / 59卷 / 12期

关键词：

Gut microbiota; Short-chain fatty acids; Type; 2; diabetes; Obesity;

D O I：

10.1007/s00592-022-01934-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aim aim of the study was to evaluate serum short chain fatty acids (SCFA) concentrations in patients with Type 2 diabetes (T2D) and overweight/obese individuals. Methods In forty-three patients with T2D and twenty-eight overweight/obese patients SCFA were determined by Gas-Chromatography/Flame Ionization Detector (GC/FID). Results Acetic acid, propionic acid, butyric acid, and total SCFA were significantly reduced in T2D patients compared to overweight/obese in the unadjusted model. Adjusting for all variables only propionic acid remained significantly lower in T2D. Conclusion Only reduction of propionic acid was closely related to diabetes itself, regardless of all other factors.

引用

页码：1653 / 1656

页数：4

共 5 条

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