Prevalence of and risk factors for thyroid carcinoma in patients with familial adenomatous polyposis: results of a multicenter study in Japan and a systematic review

被引：10

作者：

Sada, Haruki ^{[1
]}

Hinoi, Takao ^{[1
,12
,13
]}

Ueno, Hideki ^{[2
]}

Yamaguchi, Tatsuro ^{[3
]}

Inoue, Yasuhiro ^{[4
]}

Konishi, Tsuyoshi ^{[5
]}

Kobayashi, Hirotoshi ^{[6
]}

Kanemitsu, Yukihide ^{[7
]}

Ishida, Fumio ^{[8
]}

Ishida, Hideyuki ^{[9
]}

Tomita, Naohiro ^{[10
]}

Matsubara, Nagahide ^{[10
]}

Sugihara, Kenichi ^{[11
]}

机构：

[1] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Gastroenterol & Transplant Surg, Minami Ku, 1-2-3 Kasumi, Hiroshima 7348551, Japan

[2] Natl Def Med Coll, Dept Surg, Saitama, Japan

[3] Komagome Hosp, Tokyo Metropolitan Canc & Infect Dis Ctr, Dept Surg, Tokyo, Japan

[4] Mie Univ, Grad Sch Med, Dept Gastrointestinal & Pediat Surg, Tsu, Mie, Japan

[5] Japanese Fdn Canc Res, Canc Inst Hosp, Dept Gastroenterol Surg, Gastroenterol Ctr, Tokyo, Japan

[6] Tokyo Metropolitan Hiroo Gen Hosp, Dept Surg, Tokyo, Japan

[7] Natl Canc Ctr, Div Colorectal Surg, Tokyo, Japan

[8] Showa Univ, Northern Yokohama Hosp, Digest Dis Ctr, Yokohama, Kanagawa, Japan

[9] Saitama Med Univ, Saitama Med Ctr, Dept Digest Tract & Gen Surg, Saitama, Japan

[10] Hyogo Coll Med, Dept Surg, Div Lower GI Surg, Nishinomiya, Hyogo, Japan

[11] Tokyo Med & Dent Univ, Tokyo, Japan

[12] Natl Hosp Org Kure Med Ctr, Inst Clin Res, Dept Surg, 3-1 Aoyama Cho, Kure, Hiroshima 7370023, Japan

[13] Chugoku Canc Ctr, 3-1 Aoyama Cho, Kure, Hiroshima 7370023, Japan

来源：

SURGERY TODAY | 2019年 / 49卷 / 01期

关键词：

Familial adenomatous polyposis; Meta-analysis; Prevalence; Risk factor; Thyroid cancer; CANCER; IMPACT; GENES; FAP; AGE;

D O I：

10.1007/s00595-018-1710-3

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

PurposeTo investigate the recent Japanese prevalence of thyroid cancer and its characteristics in familial adenomatous polyposis (FAP) patients, through the development of surveillance programs.MethodsThe subjects of this study were 282 (93.1%) FAP patients for whom information on thyroid cancer was available, from among 303 patients registered in the Retrospective Cohort Study of Familial Adenomatous Polyposis in Japan database. We evaluated the prevalence and risk factors for thyroid cancer and integrated and/or compared our findings with those of previous reports, using a systematic review, including a meta-analysis.ResultsThyroid cancer was diagnosed in 16 women (11.4%) and 2 men (1.4%), at 17-41years and 39-57years of age, respectively. The prevalence of thyroid cancer was 6.4%, with a female-to-male ratio of 8:1, which is comparable to reports from other countries. A young age of <33years at the FAP diagnosis and female gender were identified as independent risk factors for thyroid cancer.ConclusionsFAP-associated thyroid cancer predominantly affects young women, both in Japan and other countries. Since FAP is generally diagnosed when patients are in their 20s or older, regular screening for thyroid cancer is recommended for all FAP patients, but especially women, from their early 20s.

引用

页码：72 / 81

页数：10

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