MicroRNAs-The Heart of Post-Myocardial Infarction Remodeling

被引：19
作者：
Maries, Liana [1 ,2 ]
Marian, Catalin [1 ,2 ]
Sosdean, Raluca [1 ,3 ]
Goanta, Flavia [1 ,3 ]
Sirbu, Ioan Ovidiu [1 ,2 ]
Anghel, Andrei [1 ,2 ]
机构：
[1] Victor Babes Univ Med & Pharm Timisoara, Biochem Dept, Timisoara 300041, Romania
[2] Victor Babes Univ Med & Pharm Timisoara, Ctr Complex Networks Sci, Timisoara 300041, Romania
[3] Inst Cardiovasc & Heart Dis Timisoara, Timisoara 300310, Romania
来源：
DIAGNOSTICS | 2021年 / 11卷 / 09期
关键词：
miRNA; myocardial infarction; heart failure; left ventricular remodeling; biomarker; prognostic; ACUTE MYOCARDIAL-INFARCTION; REGULATES CARDIAC FIBROSIS; CIRCULATING MIR-208B; RAT MODEL; PROTECTS; EXPRESSION; PATHWAYS; GROWTH; INJURY; PHOSPHATASE;
D O I：
10.3390/diagnostics11091675
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Myocardial infarction (MI) is one of the most frequent cardiac emergencies, with significant potential for mortality. One of the major challenges of the post-MI healing response is that replacement fibrosis could lead to left ventricular remodeling (LVR) and heart failure (HF). This process involves canonical and non-canonical transforming growth factor-beta (TGF-beta) signaling pathways translating into an intricate activation of cardiac fibroblasts and disproportionate collagen synthesis. Accumulating evidence has indicated that microRNAs (miRNAs) significantly contribute to the modulation of these signaling pathways. This review summarizes the recent updates regarding the molecular mechanisms underlying the role of the over 30 miRNAs involved in post-MI LVR. In addition, we compare the contradictory roles of several multifunctional miRNAs and highlight their potential use in pressure overload and ischemia-induced fibrosis. Finally, we discuss their attractive role as prognostic biomarkers for HF, highlighting the most relevant human trials involving these miRNAs.
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页数：20
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