Studies on the alkaloid composition of the Hawaiian Baby Woodrose Argyreia nervosa, a common legal high

被引：10

作者：

Paulke, Alexander ^{[1
]}

Kremer, Christian ^{[1
]}

Wunder, Cora ^{[1
]}

Wurglics, Mario ^{[2
]}

Schubert-Zsilavecz, Manfred ^{[2
]}

Toennes, Stefan W. ^{[1
]}

机构：

[1] Goethe Univ Frankfurt, Inst Legal Med, D-60596 Frankfurt, Germany

[2] Goethe Univ Frankfurt, Inst Pharmaceut Chem, D-60438 Frankfurt, Germany

来源：

FORENSIC SCIENCE INTERNATIONAL | 2015年 / 249卷

关键词：

Lysergic acid amide; Ergometrine; Argyreia nervosa; Ergot alkaloids; Ergopeptides; Peptide alkaloids; Legal highs; LYSERGIC-ACID AMIDE; ERGOT ALKALOIDS; SEEDS; OLOLIUQUI; INGESTION; PATTERNS; BALANSIA; CULTURE; ROSE;

D O I：

10.1016/j.forsciint.2015.02.011

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

Seeds from the Hawaiian Baby Woodrose Argyreia nervosa of different origin and labelling and with allegedly high levels of ergot alkaloids were analysed using high performance liquid chromatography-high resolution mass spectrometry (HPLC-HRMS/MS) technique. Lysergic acid amide (LSA), ergometrine, lysergol/elymoclavine/setoclavine, chanoclavine, lysergic acid and their respective stereoisomers were identified as well as penniclavine and lysergic acid a-hydroxyethylamide. In addition, methylergometrine, methysergide, and lysergylalanine were detected, some high molecular weight ergot alkaloid derivatives and hydroxyalanine derived ergopeptide fragments were detected indicating the presence of ergopeptides in the seeds. The results of the study demonstrate that the content of ergot alkaloids in Argyreia nervosa seeds depends on the quality of the material. For a consumer the quality of the seeds is unforeseeable. For the toxicological expert it is essential to investigate not only the identity of such a confiscated seed material, but also the various ergot alkaloid constituents to assess the hazardous nature and the toxic potential of the material. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

引用

页码：281 / 293

页数：13

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