Accuracy of colposcopic findings in detecting vaginal intraepithelial neoplasia: a retrospective study

被引:21
|
作者
Stuebs, Frederik A. [1 ]
Koch, Martin C. [1 ]
Mehlhorn, Grit [1 ]
Gass, Paul [1 ]
Schulmeyer, Carla E. [1 ]
Hartman, Arndt [3 ]
Strehl, Johanna [4 ]
Adler, Werner [5 ]
Beckmann, Matthias W. [1 ]
Renner, Simone K. [1 ,2 ]
机构
[1] Erlangen Univ Hosp, Comprehens Canc Ctr Erlangen, Dept Gynecol & Obstet, European Metropolitan Area Nuremberg CCC ER EMN, Univ Str 21-23, D-91054 Erlangen, Germany
[2] Klinikum Sindelfingen Boblingen, Dept Gynecol & Obstet, Bunsenstr 120, D-71032 Boblingen, Germany
[3] Erlangen Univ Hosp, Comprehens Canc Ctr Erlangen, European Metropolitan Area Nuremberg CCC ER EMN, Inst Pathol, Krankenhausstr 8-10, D-91054 Erlangen, Germany
[4] Klinikum Furth, Dept Gynecol & Obstet, Jakob Henle Str 1, D-90766 Furth, Germany
[5] Friedrich Alexander Univ Erlangen Nuremberg, Dept Med Informat Biometry & Epidemiol, Waldstr 6, D-91054 Erlangen, Germany
关键词
Vaginal intraepithelial neoplasia (VaIN); Colposcopy-directed biopsy; High-grade squamous intraepithelial lesion (HSIL); Vaginal cancer; HUMAN-PAPILLOMAVIRUS; CANCER; VULVAR; EXPERIENCE; MANAGEMENT; LESIONS;
D O I
10.1007/s00404-020-05441-5
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Purpose Malignancies of the vagina are rare, but colposcopy-directed biopsies play a major role in detecting vaginal intraepithelial lesions. Data of accuracy in detecting neoplasia of the vagina are very rare compared to accuracy in detecting cervical neoplasia. The aim of this study was to evaluate the accuracy of colposcopy-directed biopsy in comparison with clinical findings of the examiner. Methods The accuracy of colposcopy-directed biopsy was compared with the clinical finding in relation to the patient's age and the examiner's level of training. This was done in combination with PAP-smear, HPV-test results, and the history of other malignancies of the lower genital tract. The data were collected between January 2014 and February 2018 at the certified Dysplasia Unit of the University Hospital Erlangen. Results In total, 253 biopsies from 253 women from the vagina were obtained. The overall accuracy of biopsy in comparison with clinical finding was 52.17% for all entities-benign lesions, low-grade squamous intraepithelial lesions (LSILs), high-grade squamous intraepithelial lesions (HSILs), and vaginal carcinoma. The accuracy for detecting HSIL was 82.46% (47/57), with an underdiagnosis rate of 15.79% and an overdiagnosis rate of 1.79%. Conclusion With a sensitivity of over 80%, colposcopy-directed biopsy plays an important role in detecting vaginal-HSIL. A highly experienced practitioner is increasing the sensitivity in detecting vaginal-HSIL. Careful examination is required in women with a history of HSIL of the lower genital tract or with simultaneous neoplasia because they are of greater risk of developing vaginal malignancies. The combination of careful clinical work up, PAP-smear, HPV-testing, and colposcopy-guided biopsy is crucial in detecting vaginal-HSIL.
引用
收藏
页码:769 / 777
页数:9
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