Synthesis of some new thieno[2,3-b]pyridines, pyrido[3′,2′:4,5]-thieno[3,2-d]pyrimidines and pyrido[3′,2′:4,5]thieno[3,2-d][1,2,3]-triazines

被引：21

作者：

Abdel-Rahman, AE ^{[1
]}

Bakhite, EA ^{[1
]}

Mohamed, OS ^{[1
]}

Thabet, EA ^{[1
]}

机构：

[1] Assiut Univ, Fac Sci, Dept Chem, Assiut 71516, Egypt

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2000年 / 166卷

关键词：

cyclopenta[b]pyridines; cyclopenta[e]thieno[2; 3-b]pyridines; cyclopenta-[5 '; 6 ']pyrido[3 '; 2 ': 4; 5]thieno[3; 2-d]pyrimidines; cyclopenta[5 '; 5]-thieno[3; 2-d][1; 2; 3]triazines;

D O I：

10.1080/10426500008076538

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

4-Aryl-3-cyano-2-substituted-methylthiocyclopenta[b]pyridines (3a-c and 4a-i) were prepared by reaction of 4-aryl-3-cyanocyclopenta[b]pyridine-2(1H)-thiones (2a-c) with chloroacetonitrile or chloro-N-arylacetamides, respectively. On treatment of these products with sodium ethoxide in boiling ethanol, they underwent intramolecular Thorpe-Ziegler cyclization to afford the corresponding 3-amino-4-aryl-2-functionallized-cyclopenta[e]thieno [2,3-b]pyridines (5a-c and 6a-i), Most of the latter thienopyridines were used as synthons for the target cyclopenta[5 ' ,6 ' ]pyrido [3 ' ,2 ' :4,5]thieno[3,2-d]pyrimidines and cyclopenta[5 ' ,6 '] pyrido[3 ' ,2 ' :4,5] thieno[3,2-d][1,2, 3]triazines.

引用

页码：149 / 171

页数：23

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BROWN, RE ;

WILSON, J ;

SHAH, U ;

JONES, H ;

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KHANDWALA, A ;

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JOURNAL OF MEDICINAL CHEMISTRY, 1984, 27 (12) :1639-1643

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