Practical Synthesis of PC190723, an Inhibitor of the Bacterial Cell Division Protein FtsZ

被引：21

作者：

Sorto, Nohemy A. ^{[1
]}

Olmstead, Marilyn M. ^{[1
]}

Shaw, Jared T. ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Chem, Davis, CA 95616 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 75卷 / 22期

关键词：

ASSEMBLY DYNAMICS; TARGETING FTSZ; TUBULIN;

D O I：

10.1021/jo101720y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A high-yielding and practical synthesis of the bacterial cell division inhibitor PC190723 is described The synthesis is completed in a longest linear sequence of five steps from commercially available starting materials and can be readily executed on a multigram scale

引用

页码：7946 / 7949

页数：4

共 47 条

[21] Creating an Antibacterial with in Vivo Efficacy: Synthesis and Characterization of Potent Inhibitors of the Bacterial Cell Division Protein FtsZ with Improved Pharmaceutical Properties
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Bennett, James M.
Brown, David
Collins, Ian
Galbraith, Greta
Lancett, Paul
Macdonald, Rebecca
Stokes, Neil R.
Chauhan, Pramod K.
Sutariya, Jignesh K.
Nayal, Narendra
Srivastava, Anil
Beanland, Joy
Hall, Robin
Henstock, Vincent
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JOURNAL OF MEDICINAL CHEMISTRY, 2010, 53 (10) : 3927 - 3936
[22] Estimating the bending modulus of a FtsZ bacterial-division protein filament
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[23] Phenylpropanoids inhibit protofilament formation of Escherichia coli cell division protein FtsZ
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[24] Discovery of anti-TB agents that target the cell-division protein FtsZ
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[25] Lateral interactions between protofilaments of the bacterial tubulin homolog FtsZ are essential for cell division
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Yu, Jie
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[26] Synthetic Inhibitors of Bacterial Cell Division Targeting the GTP-Binding Site of FtsZ
Ruiz-Ayila, Laura B.
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ACS CHEMICAL BIOLOGY, 2013, 8 (09) : 2072 - 2083
[27] Nucleotide-induced folding of cell division protein FtsZ fromStaphylococcus aureus
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[28] An essential Staphylococcus aureus cell division protein directly regulates FtsZ dynamics
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ELIFE, 2018, 7
[29] M. jannaschii FtsZ, a key protein in bacterial cell division, is inactivated by peroxyl radical-mediated methionine oxidation
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FREE RADICAL BIOLOGY AND MEDICINE, 2021, 166 : 53 - 66
[30] Molecular dynamics simulation of GTPase activity in polymers of the cell division protein FtsZ
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