Practical Synthesis of PC190723, an Inhibitor of the Bacterial Cell Division Protein FtsZ

被引:21
|
作者
Sorto, Nohemy A. [1 ]
Olmstead, Marilyn M. [1 ]
Shaw, Jared T. [1 ]
机构
[1] Univ Calif Davis, Dept Chem, Davis, CA 95616 USA
来源
JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 75卷 / 22期
关键词
ASSEMBLY DYNAMICS; TARGETING FTSZ; TUBULIN;
D O I
10.1021/jo101720y
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A high-yielding and practical synthesis of the bacterial cell division inhibitor PC190723 is described The synthesis is completed in a longest linear sequence of five steps from commercially available starting materials and can be readily executed on a multigram scale
引用
收藏
页码:7946 / 7949
页数:4
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