A Possible Cure for Refractory DLBCL: CARs Are Headed in the Right Direction

被引:3
作者
Chavez, Julio C. [1 ]
Locke, Frederick L. [2 ]
机构
[1] H Lee Moffitt Canc Ctr & Res Inst, Dept Malignant Hematol, Tampa, FL USA
[2] H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplant & Cellular Immunot, Tampa, FL 33612 USA
关键词
MODIFIED T-CELLS; MULTICENTER; LYMPHOMA; THERAPY; KTE-C19; ZUMA-1; TRIAL;
D O I
10.1016/j.ymthe.2017.09.005
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
引用
收藏
页码:2241 / 2243
页数:3
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共 14 条
  • [1] Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition
    Cherkassky, Leonid
    Morello, Aurore
    Villena-Vargas, Jonathan
    Feng, Yang
    Dimitrov, Dimiter S.
    Jones, David R.
    Sadelain, Michel
    Adusumilli, Prasad S.
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2016, 126 (08) : 3130 - 3144
  • [2] Long-term outcome of patients in the LNH-98.5 trial, the first randomized study comparing rituximab-CHOP to standard CHOP chemotherapy in DLBCL patients: a study by the Groupe d'Etudes des Lymphomes de l'Adulte
    Coiffier, Bertrand
    Thieblemont, Catherine
    Van Den Neste, Eric
    Lepeu, Gerard
    Plantier, Isabelle
    Castaigne, Sylvie
    Lefort, Sophie
    Marit, Gerald
    Macro, Margaret
    Sebban, Catherine
    Belhadj, Karim
    Bordessoule, Dominique
    Ferme, Christophe
    Tilly, Herve
    [J]. BLOOD, 2010, 116 (12) : 2040 - 2045
  • [3] Crump M, 2016, J CLIN ONCOL S, V34
  • [4] Characterization of anti-CD19 chimeric antigen receptor (CAR) T cell-mediated tumor microenvironment immune gene profile in a multicenter trial (ZUMA-1) with axicabtagene ciloleucel (axi-cel, KTE-C19).
    Galon, Jerome
    Rossi, John
    Turcan, Sarah
    Danan, Corinne
    Locke, Frederick Lundry
    Neelapu, Sattva Swarup
    Miklos, David Bernard
    Bartlett, Nancy L.
    Jacobson, Caron Alyce
    Braunschweig, Ira
    Oluwole, Olalekan O.
    Siddiqi, Tanya
    Lin, Yi
    Timmerman, John
    Reagan, Patrick Michael
    Lekakis, Lazaros J.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2017, 35
  • [5] Acquisition of a CD19-negative myeloid phenotype allows immune escape of MLL-rearranged B-ALL from CD19 CAR-T-cell therapy
    Gardner, Rebecca
    Wu, David
    Cherian, Sindhu
    Fang, Min
    Hanafi, Laila-Aicha
    Finney, Olivia
    Smithers, Hannah
    Jensen, Michael C.
    Riddell, Stanley R.
    Maloney, David G.
    Turtle, Cameron J.
    [J]. BLOOD, 2016, 127 (20) : 2406 - 2410
  • [6] Long-Duration Complete Remissions of Diffuse Large B Cell Lymphoma after Anti-CD19 Chimeric Antigen Receptor T Cell Therapy
    Kochenderfer, James N.
    Somerville, Robert P. T.
    Lu, Tangying
    Yang, James C.
    Sherry, Richard M.
    Feldman, Steven A.
    McIntyre, Lori
    Bot, Adrian
    Rossi, John
    Lam, Norris
    Rosenberg, Steven A.
    [J]. MOLECULAR THERAPY, 2017, 25 (10) : 2245 - 2253
  • [7] Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19
    Kochenderfer, James N.
    Wilson, Wyndham H.
    Janik, John E.
    Dudley, Mark E.
    Stetler-Stevenson, Maryalice
    Feldman, Steven A.
    Maric, Irina
    Raffeld, Mark
    Nathan, Debbie-Ann N.
    Lanier, Brock J.
    Morgan, Richard A.
    Rosenberg, Steven A.
    [J]. BLOOD, 2010, 116 (20) : 4099 - 4102
  • [8] B-cell depletion for 2 years after autologous stem cell transplant for NHL induces prolonged hypogammaglobulinemia beyond the rituximab maintenance period
    Lim, Seah H.
    Esler, William V.
    Zhang, Yana
    Zhang, Jian
    Periman, Phillip O.
    Burris, Colleen
    Townsend, Mary
    [J]. LEUKEMIA & LYMPHOMA, 2008, 49 (01) : 152 - 153
  • [9] Locke FL, 2017, CANCER RES, V77, pCT019
  • [10] Phase 1 Results of ZUMA-1: A Multicenter Study of KTE-C19 Anti-CD19 CAR T Cell Therapy in Refractory Aggressive Lymphoma
    Locke, Frederick L.
    Neelapu, Sattva S.
    Bartlett, Nancy L.
    Siddiqi, Tanya
    Chavez, Julio C.
    Hosing, Chitra M.
    Ghobadi, Armin
    Budde, Lihua E.
    Bot, Adrian
    Rossi, John M.
    Jiang, Yizhou
    Xue, Allen X.
    Elias, Meg
    Aycock, Jeff
    Wiezorek, Jeff
    Go, William Y.
    [J]. MOLECULAR THERAPY, 2017, 25 (01) : 285 - 295