YBX1 knockdown induces renal cell carcinoma cell apoptosis via Kindlin-2

被引：24

作者：

Cui, Qiqi ^{[1
]}

Wang, Chao ^{[1
]}

Liu, Shuang ^{[1
]}

Du, Runxuan ^{[1
]}

Tian, Shaoping ^{[1
]}

Chen, Ruibing ^{[2
]}

Geng, Hua ^{[3
,4
]}

Subramanian, Saravanan ^{[3
,4
]}

Niu, Yuanjie ^{[1
]}

Wang, Yong ^{[1
]}

Yue, Dan ^{[1
]}

机构：

[1] Tianjin Med Univ, Hosp 2, Tianjin Inst Urol, Tianjin, Peoples R China

[2] Tianjin Univ, Sch Pharmaceut Sci & Technol, Tianjin, Peoples R China

[3] Ann & Robert H Lurie Childrens Hosp Chicago, Ctr Intestinal & Liver Inflammat Res, Stanley Manne Childrens Res Inst, Chicago, IL 60611 USA

[4] Northwestern Univ, Dept Pediat, Feinberg Sch Med, Chicago, IL 60611 USA

来源：

CELL CYCLE | 2021年 / 20卷 / 22期

基金：

中国国家自然科学基金;

关键词：

Renal cell carcinoma; y-box binding protein 1; s-2; apoptosis; reactive oxygen species; BOX-BINDING PROTEIN-1; NUCLEAR EXPRESSION; POOR-PROGNOSIS; P-GLYCOPROTEIN; FOCAL ADHESIONS; YB-1; CANCER; PROMOTES; PROGRESSION; MARKER;

D O I：

10.1080/15384101.2021.1985771

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Among urological tumors, renal cell carcinoma (RCC) is the third-highest mortality rate tumor, and 20%-30% of RCC patients present with metastases at the time of diagnosis. While the treatment of RCC has been improved over the last few years, its mortality stays high. Y-box binding protein 1 (YBX1) is a well-known oncoprotein that has tumor-promoting functions. YBX1 is widely considered to be an attractive therapeutic target in cancer. To develop novel therapeutics to target YBX1, it is of great importance to understand how YBX1 is finely regulated in cancer. Our previous studies showed that YBX1 in RCC cells significantly promoted cell adhesion, migration, and invasion. However, the role of YBX1 in RCC cells apoptosis has not been reported. In this study, we investigated the effect of YBX1 on cell apoptosis and elucidated the mechanisms involved. Results showed that YBX1 regulated RCC cells apoptosis and reactive oxygen species (ROS) generation via Kindlin-2. These findings indicated that YBX1 inhibited RCC cells apoptosis and may serve as a candidate RCC prognostic marker and a potential therapeutic target.

引用

页码：2413 / 2427

页数：15

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