Construction of 3,12-Diazatetracyclododecane-dienes through Unexpected Visible-Light-Induced Radical Cascade Cyclization

被引：3
|
作者：
Zhong, Qidi [1 ]
Wang, Yinxin [1 ]
Lan, Hanyang [1 ]
Zhu, Hao [2 ]
Fan, Qiangwen [3 ]
机构：
[1] North China Univ Sci & Technol, Sch Pharm, Tangshan 063210, Hebei, Peoples R China
[2] North China Univ Sci & Technol, Sch Publ Hlth, Tangshan 063210, Hebei, Peoples R China
[3] East China Univ Technol, Sch Chem Biol & Mat Sci, Nanchang 330013, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 87卷 / 16期
关键词：
CAGE DIMERIC 4-ARYL-1,4-DIHYDROPYRIDINES; PHOTOCHEMICAL-REACTIONS; BIOLOGICAL EVALUATION; CALCIUM-ANTAGONIST; 1,4-DIHYDROPYRIDINES; DERIVATIVES; PHOTOCYCLOADDITION;
D O I：
10.1021/acs.joc.2c01225
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel visible-light-induced cascade radical cyclization reaction of 3-cyano-4-aryl-1,4-dihydropyridines for the construction of 3,12-diazatetracyclododecane-diene derivatives is reported for the first time. In the presence of 410 nm blue LED lamp as the light source and ethanol as the solvent, the reactions proceed smoothly to afford photocyclization products in good yields. The process is carried out through the breaking of original C=C double bonds and the formation of three new single bonds in one pot and proved to be able to tolerate different substituents.
引用
收藏
页码：10937 / 10946
页数：10
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