Regioselective synthesis of poly-substituted naphthalenes via a Pd-catalyzed cyclization of modified Baylis-Hillman adducts: selective 6-endo Heck reaction and an aerobic oxidation cascade

被引：18

作者：

Kim, Se Hee ^{[1
,2
]}

Lee, Sangku ^{[3
]}

Lee, Hyun Seung ^{[1
,2
]}

Kim, Jae Nyoung ^{[1
,2
]}

机构：

[1] Chonnam Natl Univ, Dept Chem, Kwangju 500757, South Korea

[2] Chonnam Natl Univ, Inst Basic Sci, Kwangju 500757, South Korea

[3] KRIBB, Nat Med Res Ctr, Taejon 305806, South Korea

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 48期

关键词：

Palladium; Naphthalenes; Baylis-Hillman adducts; 6-endo Heck reaction; STEREOSELECTIVE-SYNTHESIS; MEDIATED SYNTHESIS; DERIVATIVES; CYCLOADDITION; EXPEDIENT; FACILE; BENZANNULATION; HETEROCYCLES; DECYANATION; ACTIVATION;

D O I：

10.1016/j.tetlet.2010.09.127

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Poly-substituted naphthalenes were synthesized via a Pd-catalyzed cyclization of modified Baylis-Hillman adducts having an o-bromophenyl acetonitrile moiety at the secondary position, in reasonable yields. The reaction involved a sequential 6-endo Heck reaction and an aerobic oxidation process. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：6305 / 6309

页数：5

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