Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases

被引：233
作者：
Kubben, Nard [1 ]
Misteli, Tom [1 ]
机构：
[1] NCI, NIH, Bethesda, MD 20892 USA
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2017年 / 18卷 / 10期
关键词：
GILFORD-PROGERIA-SYNDROME; CHRONIC KIDNEY-DISEASE; NF-KAPPA-B; IDIOPATHIC PULMONARY-FIBROSIS; BASE EXCISION-REPAIR; DEFECTIVE-DNA REPAIR; A-TYPE LAMINS; ALZHEIMERS-DISEASE; LIFE-SPAN; WERNER SYNDROME;
D O I：
10.1038/nrm.2017.68
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Ageing is the predominant risk factor for many common diseases. Human premature ageing diseases are powerful model systems to identify and characterize cellular mechanisms that underpin physiological ageing. Their study also leads to a better understanding of the causes, drivers and potential therapeutic strategies of common diseases associated with ageing, including neurological disorders, diabetes, cardiovascular diseases and cancer. Using the rare premature ageing disorder Hutchinson-Gilford progeria syndrome as a paradigm, we discuss here the shared mechanisms between premature ageing and ageing-associated diseases, including defects in genetic, epigenetic and metabolic pathways; mitochondrial and protein homeostasis; cell cycle; and stem cell-regenerative capacity.
引用
收藏
页码：595 / 609
页数：15
相关论文
共 152 条
[51]   Coronary artery disease in a Werner syndrome-like form of progeria characterized by low levels of progerin, a splice variant of lamin A [J].
Hisama, Fuki M. ;
Lessel, Davor ;
Leistritz, Dru ;
Friedrich, Katrin ;
McBride, Kim L. ;
Pastore, Matthew T. ;
Gottesman, Gary S. ;
Saha, Bidisha ;
Martin, George M. ;
Kubisch, Christian ;
Oshima, Junko .
AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 2011, 155A (12) :3002-3006
[52]   Targeting Isoprenylcysteine Methylation Ameliorates Disease in a Mouse Model of Progeria [J].
Ibrahim, Mohamed X. ;
Sayin, Volkan I. ;
Akula, Murali K. ;
Liu, Meng ;
Fong, Loren G. ;
Young, Stephen G. ;
Bergo, Martin O. .
SCIENCE, 2013, 340 (6138) :1330-1333
[53]   Vascular smooth muscle cell phenotypic plasticity and the regulation of vascular calcification [J].
Iyemere, V. P. ;
Proudfoot, D. ;
Weissberg, P. L. ;
Shanahan, C. M. .
JOURNAL OF INTERNAL MEDICINE, 2006, 260 (03) :192-210
[54]   Regulation and function of AMPK in physiology and diseases [J].
Jeon, Sang-Min .
EXPERIMENTAL AND MOLECULAR MEDICINE, 2016, 48 :e245-e245
[55]   Oxidative stress: A major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson's disease and Alzheimer's disease [J].
Jiang, Tianfang ;
Sun, Qian ;
Chen, Shengdi .
PROGRESS IN NEUROBIOLOGY, 2016, 147 :1-19
[56]   Histone Demethylase UTX-1 Regulates C. elegans Life Span by Targeting the Insulin/IGF-1 Signaling Pathway [J].
Jin, Chunyu ;
Li, Jing ;
Green, Christopher D. ;
Yu, Xiaoming ;
Tang, Xia ;
Han, Dali ;
Xian, Bo ;
Wang, Dan ;
Huang, Xinxin ;
Cao, Xiongwen ;
Yan, Zheng ;
Hou, Lei ;
Liu, Jiancheng ;
Shukeir, Nicholas ;
Khaitovich, Philipp ;
Chen, Charlie D. ;
Zhang, Hong ;
Jenuwein, Thomas ;
Han, Jing-Dong J. .
CELL METABOLISM, 2011, 14 (02) :161-172
[57]   Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA [J].
Jung, Hea-Jin ;
Coffinier, Catherine ;
Choe, Youngshik ;
Beigneux, Anne P. ;
Davies, Brandon S. J. ;
Yang, Shao H. ;
Barnes, Richard H., II ;
Hong, Janet ;
Sun, Tao ;
Pleasure, Samuel J. ;
Young, Stephen G. ;
Fong, Loren G. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (07) :E423-E431
[58]   A Mitochondrial Perspective of Chronic Obstructive Pulmonary Disease Pathogenesis [J].
Kang, Min-Jong ;
Shadel, Gerald S. .
TUBERCULOSIS AND RESPIRATORY DISEASES, 2016, 79 (04) :207-213
[59]   Regulation of DNA repair by parkin [J].
Kao, Shyan-Yuan .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2009, 382 (02) :321-325
[60]   The Telomere/Telomerase System in Chronic Inflammatory Diseases. Cause or Effect? [J].
Kordinas, Vasileios ;
Ioannidis, Anastasios ;
Chatzipanagiotou, Stylianos .
GENES, 2016, 7 (09)
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