The development of a highly photostable and chemically stable zwitterionic near-infrared dye for imaging applications

被引：52
作者：
Su, Dongdong [1 ]
Teoh, Chai Lean [1 ]
Samanta, Animesh [1 ]
Kang, Nam-Young [1 ]
Parka, Sung-Jin [1 ]
Chang, Young-Tae [1 ,2 ,3 ]
机构：
[1] ASTAR, Singapore Bioimaging Consortium, Singapore 138667, Singapore
[2] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore
[3] Natl Univ Singapore, Inst Life Sci, MedChem Program, Singapore 117543, Singapore
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 19期
基金：
英国医学研究理事会;
关键词：
HEPTAMETHINE CYANINE DYES; CONTRAST AGENTS; FLUOROPHORES; CHROMOPHORE; TARGET;
D O I：
10.1039/c4cc08814j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel zwitterionic near-infrared (NIR) dye, ZWCC, has been designed and synthesized. It shows significantly enhanced photostability and chemical stability compared to the existing zwitterionic NIR dye. In addition, the feasibility of labeling ZWCC with biological ligands was investigated and used in live cell imaging applications.
引用
收藏
页码：3989 / 3992
页数：4
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