Late malignant transformation of vestibular schwannoma in the absence of irradiation: case report

被引：15

作者：

Bashir, Asma ^{[1
]}

Poulsgaard, Lars ^{[1
]}

Broholm, Helle ^{[2
]}

Fugleholm, Kare ^{[1
]}

机构：

[1] Univ Copenhagen, Rigshosp, Fac Hlth & Med Sci, Dept Neurosurg, Blegdamsvej 9, DK-2100 Copenhagen, Denmark

[2] Univ Copenhagen, Rigshosp, Fac Hlth & Med Sci, Dept Pathol, Copenhagen, Denmark

来源：

JOURNAL OF NEUROSURGERY | 2016年 / 125卷 / 02期

关键词：

vestibular schwannoma; tumor recurrence; MIB-1; index; malignant transformation; malignant peripheral nerve sheath tumor; oncology; NERVE SHEATH TUMOR; GAMMA-KNIFE RADIOSURGERY; OF-THE-LITERATURE; STEREOTACTIC RADIOSURGERY; ACOUSTIC NERVE; TRITON TUMOR; RADIOTHERAPY;

D O I：

10.3171/2015.6.JNS1544

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Late malignant transformation of vestibular schwannoma (VS) following irradiation has previously been reported 29 times in the literature. Here, the authors report the first late malignant transformation of VS unrelated to neurofibromatosis or radiation exposure. After undergoing a near-total excision of a histologically benign VS, the patient developed malignant regrowth of the tumor remnant 42 months after the primary excision. This case challenges the dogmatic belief of absolute causality between radiation exposure and late malignant transformation of VS, and has important implications regarding future counseling and consent for the treatment of patients with VS.

引用

页码：372 / 377

页数：6

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