Protease inhibitors from a water bloom of the cyanobacterium Microcystis aeruginosa

被引：74

作者：

Reshef, V ^{[1
]}

Carmeli, S ^{[1
]}

机构：

[1] Tel Aviv Univ, Sch Chem, Raymond & Beverly Sackler Fac Exact Sci, IL-69978 Tel Aviv, Israel

来源：

TETRAHEDRON | 2001年 / 57卷 / 14期

关键词：

cyanobacteria; Microcystis; protease inhibitors;

D O I：

10.1016/S0040-4020(01)00141-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Five new protease inhibitors, micropeptins SD944 (1), SD979 (2), SD999 (3) and SD1002 (4) and microginin SD755 (5) were isolated along with two known inhibitors, micropeptin SF995 (6) and microcin SF608 (7), from the hydrophilic extract of Microcystis aeruginosa. The planar structure of compounds 1-5 was determined by homonuclear and inverse-heteronuclear 2D-NMR techniques as well as high-resolution mass spectrometry. The absolute configuration of the asymmetric centers was studied using Marfey's method for HPLC. Compounds 1-4, 6 and 7 are serine-protease inhibitors while compound 5 was found to inhibit amino-proteases. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2885 / 2894

页数：10

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