1,4-benzodiazepin-2-ones in medicinal chemistry

被引：41

作者：

Spencer, John ^{[1
]}

Rathnam, Rajendra P. ^{[1
]}

Chowdhry, Babur Z. ^{[1
]}

机构：

[1] Univ Greenwich Medway, Sch Sci, Chatham ME4 4TB, Kent, England

来源：

FUTURE MEDICINAL CHEMISTRY | 2010年 / 2卷 / 09期

关键词：

RECEPTOR ANTAGONISTS; COMBINATORIAL SYNTHESIS; BIOLOGICAL EVALUATION; PRIVILEGED STRUCTURES; CCK2; ANTAGONISTS; HIGHLY POTENT; BENZODIAZEPINE; INHIBITORS; DERIVATIVES; NONPEPTIDE;

D O I：

10.4155/FMC.10.226

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

1,4-benzodiazepin-2-ones have applications in many areas of medicinal chemistry that are not restricted to 'classical' CNS treatments such as sedatives, epilepsy and muscle relaxants. We will describe selected examples of 1,4-benzodiazepin-2-ones in other areas of medicinal chemistry including uses as G-protein-coupled receptor antagonists, enzyme inhibitors and anticancer agents. Examples from our group will mainly show the use of palladacycle complexes of 1,4-benzodiazepin-2-ones as anticancer agents.

引用

页码：1441 / 1449

页数：9

共 71 条

[21] Synthesis of a benzodiazepine-derived rhodium NHC complex by C-H bond activation
Gribble, Michael W., Jr.
Ellman, Jonathan A.
Bergman, Robert G.
[J]. ORGANOMETALLICS, 2008, 27 (10) : 2152 - 2155
[22] Design, synthesis and preliminary biological evaluation of new hydroxamate histone deacetylase inhibitors as potential antileukemic agents
Guandalini, L.
Cellai, C.
Laurenzana, A.
Scapecchi, S.
Paoletti, F.
Romanelli, M. N.
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (18) : 5071 - 5074
[23] THE BENZODIAZEPINES
HAMOR, TA
MARTIN, IL
[J]. PROGRESS IN MEDICINAL CHEMISTRY, 1983, 20 : 157 - 223
[24] HARVEY SC, 1985, GOODMAN GILMANS PHAR, P339
[25] Buccal route for benzodiazepines in treatment of seizures?
Holmes, GL
[J]. LANCET, 1999, 353 (9153) : 608 - 609
[26] The combinatorial synthesis of bicyclic privileged structures or privileged substructures
Horton, DA
Bourne, GT
Smythe, ML
[J]. CHEMICAL REVIEWS, 2003, 103 (03) : 893 - 930
[27] THE HUMAN ENDOTHELIN FAMILY - 3 STRUCTURALLY AND PHARMACOLOGICALLY DISTINCT ISOPEPTIDES PREDICTED BY 3 SEPARATE GENES
INOUE, A
YANAGISAWA, M
KIMURA, S
KASUYA, Y
MIYAUCHI, T
GOTO, K
MASAKI, T
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (08) : 2863 - 2867
[28] Development of Ligands for the Peripheral Benzodiazepine Receptor
James, Michelle L.
Selleri, Silvia
Kassiou, Michael
[J]. CURRENT MEDICINAL CHEMISTRY, 2006, 13 (17) : 1991 - 2001
[29] Development of a fluorescence polarization assay for the molecular chaperone Hsp90
Kim, J
Felts, S
Llauger, L
He, HZ
Huezo, H
Rosen, H
Chiosis, G
[J]. JOURNAL OF BIOMOLECULAR SCREENING, 2004, 9 (05) : 375 - 381
[30] KING MB, 1992, BRIT J GEN PRACT, V42, P202

← 1 2 3 4 5 6 7 8 →