1,4-benzodiazepin-2-ones in medicinal chemistry

被引：41
作者：
Spencer, John [1 ]
Rathnam, Rajendra P. [1 ]
Chowdhry, Babur Z. [1 ]
机构：
[1] Univ Greenwich Medway, Sch Sci, Chatham ME4 4TB, Kent, England
来源：
FUTURE MEDICINAL CHEMISTRY | 2010年 / 2卷 / 09期
关键词：
RECEPTOR ANTAGONISTS; COMBINATORIAL SYNTHESIS; BIOLOGICAL EVALUATION; PRIVILEGED STRUCTURES; CCK2; ANTAGONISTS; HIGHLY POTENT; BENZODIAZEPINE; INHIBITORS; DERIVATIVES; NONPEPTIDE;
D O I：
10.4155/FMC.10.226
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
1,4-benzodiazepin-2-ones have applications in many areas of medicinal chemistry that are not restricted to 'classical' CNS treatments such as sedatives, epilepsy and muscle relaxants. We will describe selected examples of 1,4-benzodiazepin-2-ones in other areas of medicinal chemistry including uses as G-protein-coupled receptor antagonists, enzyme inhibitors and anticancer agents. Examples from our group will mainly show the use of palladacycle complexes of 1,4-benzodiazepin-2-ones as anticancer agents.
引用
收藏
页码：1441 / 1449
页数：9
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