Rapid solid phase synthesis of α-amino acids

被引：20

作者：

Barbaste, M ^{[1
]}

Rolland-Fulcrand, V ^{[1
]}

Roumestant, ML ^{[1
]}

Viallefont, P ^{[1
]}

Martinez, J ^{[1
]}

机构：

[1] Univ Montpellier 1 & 2, Lab Aminoacides Peptides & Prot, CNRS, UMR 5810, F-34095 Montpellier 5, France

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 35期

关键词：

D O I：

10.1016/S0040-4039(98)01328-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A solid phase synthetic method for amino acids is developed. The N-acetyl-dehydroalanine is quantitatively bound to Wang resin by the Mitsunobu method. Then a Michael addition is achieved on the double bond with different nucleophiles. Non proteinic N-acetyl-alpha-amino acids are obtained after cleavage from the resin by mild acid treatment (Scheme 1). (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：6287 / 6290

页数：4

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