Gene Silencing Mediated by Magnetic Lipospheres Tagged with Small Interfering RNA

被引：50
作者：
del Pino, Pablo [2 ,3 ]
Munoz-Javier, Almudena [2 ,3 ]
Vlaskou, Dialechti [1 ]
Rivera Gil, Pilar [2 ,3 ]
Plank, Christian [1 ]
Parak, Wolfgang J. [2 ,3 ]
机构：
[1] Tech Univ Munich, Inst Expt Oncol & Therapy Res, D-81675 Munich, Germany
[2] Univ Marburg, Fachbereich Phys, D-35037 Marburg, Germany
[3] Univ Marburg, WZMW, D-35037 Marburg, Germany
来源：
NANO LETTERS | 2010年 / 10卷 / 10期
关键词：
Magnetic retention; gene therapy; RNA interference; magnetic NPs; delivery; lipospheres; THERAPY PROGRESS; SIRNA DELIVERY; MAGNETOFECTION; PROSPECTS; POTENT; ISSUES; FORCE; CELLS;
D O I：
10.1021/nl102485v
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Lipospheres made from soy bean oil and a combination of the cationic lipid Metafectenc and the helper lipid dioleoylphosphaudyl-ethanolamine were functionalized with magnetic nanoparticles (NPs) and small interfering RNA (sIRNA) The resulting magnetic lipospheres loaded with siRNA are proven here as efficient nonviral vectors for gene silencing Embedding magnetic NPs in the shell of lipospheres allows for magnetic force-assisted transfection (magnetofection) as well as magnetic targeting in both static and fluidic conditions mimicking the bloodstream
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收藏
页码：3914 / 3921
页数：8
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