Ability of CD8+ T cell anti-feline immunodeficiency virus (FIV) activity and FIV proviral DNA load in mononuclear cells in FIV-infected cats

被引：3

作者：

Hohdatsu, T ^{[1
]}

Nakanishi, T ^{[1
]}

Saito, I ^{[1
]}

Koyama, H ^{[1
]}

机构：

[1] Kitasato Univ, Sch Vet Med & Anim Sci, Dept Vet Infect Dis, Towada, Aomori 0348628, Japan

来源：

JOURNAL OF VETERINARY MEDICAL SCIENCE | 2005年 / 67卷 / 01期

关键词：

CD8(+) T cell; FIV; proviral DNA load;

D O I：

10.1292/jvms.67.129

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

We investigated the relationship between CD8(+) T cell anti-feline immunodeficiency virus (FIV) activity and FIV proviral DNA load integrated in mononuclear cells. The anti-FIV activity and the proviral DNA load were correlated, and the number of proviral DNA copies was high in cats with decreased anti-FIV activity. Particularly, no anti-FIV activity was detected in the cats staged as having an acquired immunodeficiency syndrome (AIDS)-related complex or AIDS, and the number of proviral DNA copies was obviously increased compared to those in the cats in the asymptomatic stage. These results suggest that decreased anti-FIV activity destroys the control of in vivo FIV replication, which leads to an increased proviral DNA load with the progression of the clinical stage of disease.

引用

页码：129 / 131

页数：3

共 11 条

[1] A longitudinal study of feline immunodeficiency virus-specific cytotoxic T lymphocytes in experimentally infected cats, using antigen-specific induction [J].

Beatty, JA ;

Willett, BJ ;

Gault, EA ;

Jarrett, O .

JOURNAL OF VIROLOGY, 1996, 70 (09) :6199-6206

[2] Mucosally transmitted feline immunodeficiency virus induces a CD8+ antiviral response that correlates with reduction of cell-associated virus [J].

Bucci, JG ;

English, RV ;

Jordan, HL ;

Childers, TA ;

Tompkins, MB ;

Tompkins, WAF .

JOURNAL OF INFECTIOUS DISEASES, 1998, 177 (01) :18-25

[3] Anti-feline immunodeficiency virus (FIV) soluble factor(s) produced from antigen-stimulated feline CD8+ T lymphocytes suppresses FIV replication [J].

Choi, IS ;

Hokanson, R ;

Collisson, EW .

JOURNAL OF VIROLOGY, 2000, 74 (02) :676-683

[4] Suppression of feline immunodeficiency virus replication in vitro by a soluble factor secreted by CD8+ T lymphocytes [J].

Flynn, JN ;

Cannon, CA ;

Sloan, D ;

Neil, JC ;

Jarrett, O .

IMMUNOLOGY, 1999, 96 (02) :220-229

[5] Ability of CD8+ T cell anti-feline immunodeficiency virus activity correlated with peripheral CD4+ T cell counts and plasma viremia [J].

Hohdatsu, T ;

Yamazaki, A ;

Yamada, M ;

Kusuhara, H ;

Kaneshima, T ;

Koyama, H .

MICROBIOLOGY AND IMMUNOLOGY, 2003, 47 (10) :765-773

[6] Feline CD8+ T cell non-cytolytic anti-feline immunodeficiency virus activity mediated by a soluble factor(s) [J].

Hohdatsu, T ;

Okubo, M ;

Koyama, H .

JOURNAL OF GENERAL VIROLOGY, 1998, 79 :2729-2735

[7] CD8+ T cells from feline immunodeficiency virus (FIV) infected cats suppress exogenous FIV replication of their peripheral blood mononuclear cells in vitro [J].

Hohdatsu, T ;

Sasagawa, T ;

Yamazaki, A ;

Motokawa, K ;

Kusuhara, H ;

Kaneshima, T ;

Koyama, H .

ARCHIVES OF VIROLOGY, 2002, 147 (08) :1517-1529

[8] Studies on feline CD8+ T cell non-cytolytic anti-feline immunodeficiency virus (FIV) activity [J].

Hohdatsu, T ;

Miyagawa, N ;

Ohkubo, M ;

Kida, K ;

Koyama, H .

ARCHIVES OF VIROLOGY, 2000, 145 (12) :2525-2538

[9] Evidence for CD8(+) antiviral activity in cats infected with feline immunodeficiency virus [J].

Jeng, CR ;

English, RV ;

Childers, T ;

Tompkins, MB ;

Tompkins, WAF .

JOURNAL OF VIROLOGY, 1996, 70 (04) :2474-2480

[10] ISOLATION OF A T-LYMPHOTROPIC VIRUS FROM DOMESTIC CATS WITH AN IMMUNODEFICIENCY-LIKE SYNDROME [J].

PEDERSEN, NC ;

HO, EW ;

BROWN, ML ;

YAMAMOTO, JK .

SCIENCE, 1987, 235 (4790) :790-793

← 1 2 →