The therapeutic effect of moclobemide, a reversible selective monoamine oxidase a inhibitor, in Parkinson's disease

被引：0
作者：
Sternic, N [1 ]
Kacar, A [1 ]
Filipovic, S [1 ]
Svetel, M [1 ]
Kostic, VS [1 ]
机构：
[1] Inst Neurol CCS, YU-11000 Belgrade, Yugoslavia
来源：
CLINICAL NEUROPHARMACOLOGY | 1998年 / 21卷 / 02期
关键词：
Parkinson's disease; moclobemide; MAO-A;
D O I：
暂无
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
In this open study, the therapeutic effect of moclobemide, a reversible selective monoamine oxidase A inhibitor, was tested in 20 patients with Parkinson's disease who developed levodopa-induced motor response complications. Moclobemide as adjunct therapy reduced "off" time duration for 27%, without an overall motor and functional improvement during their "on" periods. Since it was well tolerated, moclobemide may be specially indicated in elderly or depressed fluctuating parkinsonian patients.
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页码：93 / 96
页数：4
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