Clinical Cardiovascular Applications of Hyperpolarized Magnetic Resonance

被引：23

作者：

Lewis, Andrew J. M. ^{[1
]}

Tyler, Damian J. ^{[1
]}

Rider, Oliver ^{[1
]}

机构：

[1] Univ Oxford, Ctr Clin Magnet Resonance Res OCMR, Dept Med, Oxford, England

来源：

CARDIOVASCULAR DRUGS AND THERAPY | 2020年 / 34卷 / 02期

基金：

英国医学研究理事会;

关键词：

Hyperpolarization; Magnetic resonance; Cardiovascular; IN-VIVO ASSESSMENT; PYRUVATE-DEHYDROGENASE FLUX; INTRACELLULAR PH; C-13; HEART; METABOLISM; INFARCTION; PERFUSION;

D O I：

10.1007/s10557-020-06942-w

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Current cardiovascular magnetic resonance imaging techniques provide an exquisite assessment of the structure and function of the heart and great vessels, but their ability to assess the molecular processes that underpin changes in cardiac function in health and disease is limited by inherent insensitivity. Hyperpolarized magnetic resonance is a new technology which overcomes this limitation, generating molecular contrast agents with an improvement in magnetic resonance signal of up to five orders of magnitude. One key molecule, hyperpolarized [1-C-13]pyruvate, shows particular promise for the assessment of cardiac energy metabolism and other fundamental biological processes in cardiovascular disease. This molecule has numerous potential applications of clinical relevance and has now been translated to human use in early clinical studies. This review outlines the principles of hyperpolarized magnetic resonance and key potential cardiovascular applications for this new technology. Finally, we provide an overview of the pipeline for forthcoming hyperpolarized agents and their potential applications in cardiovascular disease.

引用

页码：231 / 240

页数：10

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