Jekyll & Hyde: Evolution of a superfamily

被引：6

作者：

Martinis, Susan A. ^{[1
]}

Pang, Yan Ling Joy ^{[1
]}

机构：

[1] Univ Illinois, Dept Biochem, Urbana, IL 61801 USA

来源：

CHEMISTRY & BIOLOGY | 2007年 / 14卷 / 12期

关键词：

D O I：

10.1016/j.chembiol.2007.12.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aminoacyl-tRNA synthetase mutations have been linked to neurological diseases, but aminoacylation may be unaffected. This protein superfamily also performs many other diverse functions. Yang et al. insightfully engineer a single mutation to unmask a cell signaling activity of tyrosyl-tRNA synthetase [1].

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页码：1307 / 1308

页数：2

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