The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis

被引:346
作者
Jia, JH
Zhang, WS
Wang, B
Trinko, R
Jiang, J
机构
[1] Univ Texas, SW Med Ctr, Ctr Dev Biol, Dallas, TX 75390 USA
[2] Univ Texas, SW Med Ctr, Dept Pharmacol, Dallas, TX 75390 USA
[3] Univ Texas, SW Med Ctr, DCMB Program, Dallas, TX 75390 USA
关键词
dMST; MST1; tumor suppressor; apoptosis; Wts; Sav;
D O I
10.1101/gad.1134003
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
In a genetic screen for mutations that restrict cell growth and organ size, we identified a new tumor suppressor gene, dMST, which encodes the Drosophila homolog of the mammalian Ste20 kinase family members MST1 and MST2. Loss-of-function mutations in dMST result in overgrown tissues containing more cells of normal size. dMST mutant cells exhibit elevated levels of Cyclin E and DIAP1, increased cell growth and proliferation, and impaired apoptosis. dMST forms a complex with Sav and Wts, two tumor suppressors also implicated in regulating both cell proliferation and apoptosis, suggesting that they act in common pathways.
引用
收藏
页码:2514 / 2519
页数:6
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