Entrainment of Arteriole Vasomotor Fluctuations by Neural Activity Is a Basis of Blood-Oxygenation-Level-Dependent "Resting-State'' Connectivity

被引：208

作者：

Mateo, Celine ^{[1
]}

Knutsen, Per M. ^{[1
]}

Tsai, Philbert S. ^{[1
]}

Shih, Andy Y. ^{[2
]}

Kleinfeld, David ^{[1
,3
]}

机构：

[1] Univ Calif San Diego, Dept Phys, La Jolla, CA 92093 USA

[2] Med Univ South Carolina, Dept Neurosci, Charleston, SC USA

[3] Univ Calif San Diego, Neurobiol Sect, La Jolla, CA 92093 USA

来源：

NEURON | 2017年 / 96卷 / 04期

基金：

美国国家科学基金会;

关键词：

RAT SOMATOSENSORY CORTEX; LIGHT-INDUCED ACTIVATION; STIMULUS-INDUCED CHANGES; FUNCTIONAL CONNECTIVITY; IN-VIVO; TRANSGENIC MICE; SENSORY STIMULATION; BOLD SIGNAL; CEREBRAL HEMODYNAMICS; 2-PHOTON MICROSCOPY;

D O I：

10.1016/j.neuron.2017.10.012

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Resting-state signals in blood-oxygenation-level-dependent (BOLD) imaging are used to parcellate brain regions and define "functional connections'' between regions. Yet a physiological link between fluctuations in blood oxygenation with those in neuronal signaling pathways is missing. We present evidence from studies on mouse cortex that modulation of vasomotion, i.e., intrinsic ultra-slow (0.1 Hz) fluctuations in arteriole diameter, provides this link. First, ultra-slow fluctuations in neuronal signaling, which occur as an envelope over g-band activity, entrains vasomotion. Second, optogenetic manipulations confirm that entrainment is unidirectional. Third, co-fluctuations in the diameter of pairs of arterioles within the same hemisphere diminish to chance for separations > 1.4 mm. Yet the diameters of arterioles in distant (> 5 mm), mirrored transhemispheric sites strongly co-fluctuate; these correlations are diminished in acallosal mice. Fourth, fluctuations in arteriole diameter coherently drive fluctuations in blood oxygenation. Thus, entrainment of vasomotion links neuronal pathways to functional connections.

引用

页码：936 / +

页数：16

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