Neonatal Cranial Ultrasound Findings among Infants Born Extremely Preterm: Associations with Neurodevelopmental Outcomes at 10 Years of Age

被引：15

作者：

Campbell, Heather ^{[1
]}

Check, Jennifer ^{[2
]}

Kuban, Karl C. K. ^{[3
]}

Leviton, Alan ^{[4
,5
]}

Joseph, Robert M. ^{[6
]}

Frazier, Jean A. ^{[7
]}

Douglass, Laurie M. ^{[3
]}

Roell, Kyle ^{[1
]}

Allred, Elizabeth N. ^{[4
,5
]}

Fordham, Lynn Ansley ^{[8
]}

Hooper, Stephen R. ^{[9
]}

Jara, Hernan ^{[10
]}

Paneth, Nigel ^{[11
]}

Mokrova, Irina ^{[12
]}

Ru, Hongyu ^{[1
]}

Santos, Hudson P., Jr. ^{[13
]}

Fry, Rebecca C. ^{[14
]}

O'Shea, T. Michael ^{[1
]}

机构：

[1] Univ N Carolina, Dept Pediat, Sch Med, Chapel Hill, NC 27599 USA

[2] Wake Forest Sch Med, Dept Pediat, Winston Salem, NC 27101 USA

[3] Boston Univ, Med Ctr, Div Pediat Neurol, Dept Pediat, Boston, MA USA

[4] Boston Childrens Hosp, Dept Neurol, Boston, MA USA

[5] Harvard Med Sch, Boston, MA 02115 USA

[6] Boston Univ, Dept Anat & Neurobiol, Sch Med, Boston, MA 02115 USA

[7] Univ Massachusetts, Eunice Kennedy Shriver Ctr, Med Sch, Worcester, MA 01605 USA

[8] Univ N Carolina, Dept Radiol, Sch Med, Chapel Hill, NC 27599 USA

[9] Univ N Carolina, Dept Allied Hlth, Sch Med, Chapel Hill, NC 27599 USA

[10] Boston Univ, Dept Radiol, Med Ctr, Boston, MA 02115 USA

[11] Michigan State Univ, Coll Human Med, E Lansing, MI 48824 USA

[12] Duke Univ, Sch Med, Durham, NC USA

[13] Univ N Carolina, Sch Nursing, Biobehav Lab, Chapel Hill, NC 27599 USA

[14] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USA

来源：

JOURNAL OF PEDIATRICS | 2021年 / 237卷

关键词：

10-YEAR-OLD CHILDREN BORN; AUTISM SPECTRUM DISORDER; INTRAVENTRICULAR HEMORRHAGE; CEREBRAL-PALSY; DISABILITY; MRI; COOCCURRENCE; RELIABILITY; PREVALENCE; SYMPTOMS;

D O I：

10.1016/j.jpeds.2021.05.059

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Objective To examine the association between neonatal cranial ultrasound (CUS) abnormalities among infants born extremely preterm and neurodevelopmental outcomes at 10 years of age. Study design In a multicenter birth cohort of infants born at <28 weeks of gestation, 889 of 1198 survivors were evaluated for neurologic, cognitive, and behavioral outcomes at 10 years of age. Sonographic markers of white matter damage (WMD) included echolucencies in the brain parenchyma and moderate to severe ventricular enlargement. Neonatal CUS findings were classified as intraventricular hemorrhage (IVH) without WMD, IVH with WMD, WMD without IVH, and neither IVH nor WMD. Results WMD without IVH was associated with an increased risk of cognitive impairment (OR 3.5, 95% CI 1.7, 7.4), cerebral palsy (OR 14.3, 95% CI 6.5, 31.5), and epilepsy (OR 6.9; 95% CI 2.9, 16.8). Similar associations were found for WMD accompanied by IVH. Isolated IVH was not significantly associated these outcomes. Conclusions Among children born extremely preterm, CUS abnormalities, particularly those indicative of WMD, are predictive of neurodevelopmental impairments at 10 years of age. The strongest associations were found with cerebral palsy.

引用

页码：197 / +

页数：13

共 49 条

[31] Contemporary definitions of infant growth failure and neurodevelopmental and behavioral outcomes in extremely premature infants at two years of age
Strobel, Katie M.
Wood, Thomas R.
Valentine, Gregory C.
German, Kendell R.
Gogcu, Semsa
Hendrixson, D. Taylor
Kolnik, Sarah E.
Law, Janessa B.
Mayock, Dennis E.
Comstock, Bryan A.
Heagerty, Patrick J.
Juul, Sandra E.
JOURNAL OF PERINATOLOGY, 2024, 44 (06) : 811 - 818
[32] Brain microstructure and morphology of very preterm-born infants at term equivalent age: Associations with motor and cognitive outcomes at 1 and 2 years
Pannek, Kerstin
George, Joanne M.
Boyd, Roslyn N.
Colditz, Paul B.
Rose, Stephen E.
Fripp, Jurgen
NEUROIMAGE, 2020, 221
[33] Predicting school readiness from neurodevelopmental assessments at age 2 years after respiratory distress syndrome in infants born preterm
Patrianakos-Hoobler, Athena I.
Msall, Michael E.
Huo, Dezheng
Marks, Jeremy D.
Plesha-Troyke, Susan
Schreiber, Michael D.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY, 2010, 52 (04) : 379 - 385
[34] Periventricular Hemorrhagic Infarction in Very Preterm Infants: Characteristic Sonographic Findings and Association with Neurodevelopmental Outcome at Age 2 Years
Cizmeci, Mehmet N.
de Vries, Linda S.
Ly, Linh G.
van Haastert, Ingrid C.
Groenendaal, Floris
Kelly, Edmond N.
Traubici, Jeffrey
Whyte, Hilary E.
Leijser, Lara M.
JOURNAL OF PEDIATRICS, 2020, 217 : 79 - +
[35] Chorionicity and neurodevelopmental outcomes at 51/2 years among twins born preterm: the EPIPAGE2 cohort study
Hoarau, Delphine
Tosello, Barthelemy
Blanc, Julie
Lorthe, Elsa
Foix-L'Helias, Laurence
D'Ercole, Claude
Winer, Norbert
Subtil, Damien
Goffinet, Francois
Kayem, Gilles
Resseguier, Noemie
Gire, Catherine
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2023, 130 (09) : 1047 - 1058
[36] The Baby Moves prospective cohort study protocol: using a smartphone application with the General Movements Assessment to predict neurodevelopmental outcomes at age 2 years for extremely preterm or extremely low birthweight infants
Spittle, A. J.
Olsen, J.
Kwong, A.
Doyle, L. W.
Marschik, P. B.
Einspieler, C.
Cheong, J. L. Y.
BMJ OPEN, 2016, 6 (10):
[37] Neurodevelopmental outcomes at 2 and 5 years of age in very-low-birth-weight preterm infants born between 2002 and 2009: A prospective cohort study in Taiwan
Lin, Chia-Ying
Hsu, Chyong-Hsin
Chang, Jui-Hsing
PEDIATRICS AND NEONATOLOGY, 2020, 61 (01) : 36 - 44
[38] Diffusion MRI Microstructural Abnormalities at Term-Equivalent Age Are Associated with Neurodevelopmental Outcomes at 3 Years of Age in Very Preterm Infants
Parikh, M. N.
Chen, M.
Braimah, A.
Kline, J.
McNally, K.
Logan, J. W.
Tamm, L.
Yeates, K. O.
Yuan, W.
He, L.
Parikh, N. A.
AMERICAN JOURNAL OF NEURORADIOLOGY, 2021, 42 (08) : 1535 - 1542
[39] Prediction of neuromotor outcome in infants born preterm at 11 years of age using volumetric neonatal magnetic resonance imaging and neurological examinations
Setanen, Sirkku
Lehtonen, Liisa
Parkkola, Riitta
Aho, Karoliina
Haataja, Leena
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY, 2016, 58 (07) : 721 - 727
[40] The association between bronchopulmonary dysplasia grade and risks of adverse neurodevelopmental outcomes among preterm infants born at less than 30 weeks of gestation
Oluwole, Izabela
Tan, John B. C.
DeSouza, Shirin
Hutchinson, Matthew
Leigh, Rebekah M.
Cha, Minha
Rodriguez, Abigail
Hou, Gina
Rao, Srinandini S. S.
Narang, Arvind
Chou, Fu-Sheng
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 2023, 36 (01)

← 1 2 3 4 5 →