Neonatal Cranial Ultrasound Findings among Infants Born Extremely Preterm: Associations with Neurodevelopmental Outcomes at 10 Years of Age

被引：18

作者：

Campbell, Heather ^{[1
]}

Check, Jennifer ^{[2
]}

Kuban, Karl C. K. ^{[3
]}

Leviton, Alan ^{[4
,5
]}

Joseph, Robert M. ^{[6
]}

Frazier, Jean A. ^{[7
]}

Douglass, Laurie M. ^{[3
]}

Roell, Kyle ^{[1
]}

Allred, Elizabeth N. ^{[4
,5
]}

Fordham, Lynn Ansley ^{[8
]}

Hooper, Stephen R. ^{[9
]}

Jara, Hernan ^{[10
]}

Paneth, Nigel ^{[11
]}

Mokrova, Irina ^{[12
]}

Ru, Hongyu ^{[1
]}

Santos, Hudson P., Jr. ^{[13
]}

Fry, Rebecca C. ^{[14
]}

O'Shea, T. Michael ^{[1
]}

机构：

[1] Univ N Carolina, Dept Pediat, Sch Med, Chapel Hill, NC 27599 USA

[2] Wake Forest Sch Med, Dept Pediat, Winston Salem, NC 27101 USA

[3] Boston Univ, Med Ctr, Div Pediat Neurol, Dept Pediat, Boston, MA USA

[4] Boston Childrens Hosp, Dept Neurol, Boston, MA USA

[5] Harvard Med Sch, Boston, MA 02115 USA

[6] Boston Univ, Dept Anat & Neurobiol, Sch Med, Boston, MA 02115 USA

[7] Univ Massachusetts, Eunice Kennedy Shriver Ctr, Med Sch, Worcester, MA 01605 USA

[8] Univ N Carolina, Dept Radiol, Sch Med, Chapel Hill, NC 27599 USA

[9] Univ N Carolina, Dept Allied Hlth, Sch Med, Chapel Hill, NC 27599 USA

[10] Boston Univ, Dept Radiol, Med Ctr, Boston, MA 02115 USA

[11] Michigan State Univ, Coll Human Med, E Lansing, MI 48824 USA

[12] Duke Univ, Sch Med, Durham, NC USA

[13] Univ N Carolina, Sch Nursing, Biobehav Lab, Chapel Hill, NC 27599 USA

[14] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USA

来源：

JOURNAL OF PEDIATRICS | 2021年 / 237卷

关键词：

10-YEAR-OLD CHILDREN BORN; AUTISM SPECTRUM DISORDER; INTRAVENTRICULAR HEMORRHAGE; CEREBRAL-PALSY; DISABILITY; MRI; COOCCURRENCE; RELIABILITY; PREVALENCE; SYMPTOMS;

D O I：

10.1016/j.jpeds.2021.05.059

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Objective To examine the association between neonatal cranial ultrasound (CUS) abnormalities among infants born extremely preterm and neurodevelopmental outcomes at 10 years of age. Study design In a multicenter birth cohort of infants born at <28 weeks of gestation, 889 of 1198 survivors were evaluated for neurologic, cognitive, and behavioral outcomes at 10 years of age. Sonographic markers of white matter damage (WMD) included echolucencies in the brain parenchyma and moderate to severe ventricular enlargement. Neonatal CUS findings were classified as intraventricular hemorrhage (IVH) without WMD, IVH with WMD, WMD without IVH, and neither IVH nor WMD. Results WMD without IVH was associated with an increased risk of cognitive impairment (OR 3.5, 95% CI 1.7, 7.4), cerebral palsy (OR 14.3, 95% CI 6.5, 31.5), and epilepsy (OR 6.9; 95% CI 2.9, 16.8). Similar associations were found for WMD accompanied by IVH. Isolated IVH was not significantly associated these outcomes. Conclusions Among children born extremely preterm, CUS abnormalities, particularly those indicative of WMD, are predictive of neurodevelopmental impairments at 10 years of age. The strongest associations were found with cerebral palsy.

引用

页码：197 / +

页数：13

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