The impact of extended pelvic lymph node dissection on the risk of hospital readmission within 180 days after robot assisted radical prostatectomy

被引:15
作者
Sebben, Marco [1 ]
Tafuri, Alessandro [1 ,2 ,3 ]
Shakir, Aliasger [2 ,3 ]
Pirozzi, Marco [1 ]
Processali, Tania [1 ]
Rizzetto, Riccardo [1 ]
Amigoni, Nelia [1 ]
Tiso, Leone [1 ]
De Michele, Mario [1 ]
Panunzio, Andrea [1 ]
Cerrato, Clara [1 ]
Brunelli, Matteo [4 ]
Migliorini, Filippo [1 ]
Novella, Giovanni [1 ]
De Marco, Vincenzo [1 ]
Siracusano, Salvatore [1 ]
Artibani, Walter [1 ]
Porcaro, Antonio Benito [1 ]
机构
[1] Univ Verona, Azienda Osped Univ Integrata Verona, Dept Urol, Piazzale Stefani 1, I-37126 Verona, Italy
[2] Univ Southern Calif, Inst Urol, Los Angeles, CA 90007 USA
[3] Univ Southern Calif, Catherine & Joseph Aresty Dept Urol, Los Angeles, CA 90007 USA
[4] Univ Verona, Azienda Osped Univ Integrata Verona, Dept Pathol, Verona, Italy
关键词
Prostate cancer; Radical prostatectomy; Robotic surgery; Hospital readmission; Complications; SEMINAL-VESICLE INVASION; CLINICAL FACTORS; CANCER PATIENTS; PREDICTORS; COMPLICATIONS; GUIDELINES; CARCINOMA; PROPOSAL; DISEASE; COHORT;
D O I
10.1007/s00345-020-03094-2
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Objective To evaluate the factors associated with the risk of hospital readmission after robot assisted radical prostatectomy (RARP) with or without extended pelvic lymph node dissection (ePLND) for prostate cancer (PCA) over a long term. Materials and methods The risk of readmission was evaluated by clinical, pathological, and perioperative factors. Skilled and experienced surgeons performed the procedures. Patients were followed for complications and hospital readmission for a period of six months. The logistic regression model and Cox's proportional hazards assessed the association of factors with the risk of readmission. Results From January 2013 to December 2018, 890 patients underwent RARP; ePLND was performed in 495 of these patients. Hospital readmission was detected in 25 cases (2.8%); moreover, it was more frequent when RARP was performed with ePLND (4.4% of cases) than without (0.8% of patients). On the final multivariate model, ePLND was the only independent factor that was positively associated with the risk of hospital readmission (hazard ratio, HR = 5935; 95%CI 1777-19,831; p = 0.004). Conclusions Over the long term after RARP for PCA, the risk of hospital readmission is associated with ePLND. In patients who underwent RARP and ePLND, 4.4% of them had a readmission, compared to RARP alone, in which only 0.8% of cases had a readmission. When ePLND is planned for staging pelvic lymph nodes, patients should be informed of the increased risk of hospital readmission.
引用
收藏
页码:2799 / 2809
页数:11
相关论文
共 41 条
[1]   Management of Biochemical Recurrence after Primary Curative Treatment for Prostate Cancer: A Review [J].
Artibani, Walter ;
Porcaro, Antonio Benito ;
De Marco, Vincenzo ;
Cerruto, Maria A. ;
Siracusano, Salvatore .
UROLOGIA INTERNATIONALIS, 2018, 100 (03) :251-262
[2]   Updated Nomogram Predicting Lymph Node Invasion in Patients with Prostate Cancer Undergoing Extended Pelvic Lymph Node Dissection: The Essential Importance of Percentage of Positive Cores [J].
Briganti, Alberto ;
Larcher, Alessandro ;
Abdollah, Firas ;
Capitanio, Umberto ;
Gallina, Andrea ;
Suardi, Nazareno ;
Bianchi, Marco ;
Sun, Maxine ;
Freschi, Massimo ;
Salonia, Andrea ;
Karakiewicz, Pierre I. ;
Rigatti, Patrizio ;
Montorsi, Francesco .
EUROPEAN UROLOGY, 2012, 61 (03) :480-487
[3]   The association of lymph node dissection with 30-day perioperative morbidity among men undergoing minimally invasive radical prostatectomy: analysis of the National Surgical Quality Improvement Program (NSQIP) [J].
Brito, Joseph, III ;
Pereira, Jorge ;
Moreira, Daniel M. ;
Pareek, Gyan ;
Tucci, Christopher ;
Guo, Ruiting ;
Zhang, Zheng ;
Amin, Ali ;
Mega, Anthony ;
Renzulli, Joseph, II ;
Golijanin, Dragan ;
Gershman, Boris .
PROSTATE CANCER AND PROSTATIC DISEASES, 2018, 21 (02) :245-251
[4]   Extended pelvic lymphadenectomy for prostate cancer: should the Cloquet's nodes dissection be considered only an option? [J].
Cacciamani, Giovanni E. ;
Porcaro, Antonio B. ;
Sebben, Marco ;
Tafuri, Alessandro ;
Rizzetto, Riccardo ;
De Luyk, Nicolo ;
Ciocchetta, Elisa ;
Processali, Tania ;
Pirozzi, Marco ;
Amigoni, Nelia ;
Corsi, Paolo ;
Brunelli, Matteo ;
De Marco, Vincenzo ;
Artibani, Walter .
MINERVA UROLOGICA E NEFROLOGICA, 2019, 71 (02) :136-145
[5]   Comparison of 90-day re-admission rates between open retropubic radical prostatectomy (RRP), laparoscopic RP (LRP) and robot-assisted laparoscopic prostatectomy (RALP) [J].
Chung, Shiu-Dong ;
Kelle, Joseph J. ;
Huang, Chao-Yuan ;
Chen, Yi-Hua ;
Lin, Herng-Ching .
BJU INTERNATIONAL, 2012, 110 (11C) :E966-E971
[6]   Classification of surgical complications - A new proposal with evaluation in a cohort of 6336 patients and results of a survey [J].
Dindo, D ;
Demartines, N ;
Clavien, PA .
ANNALS OF SURGERY, 2004, 240 (02) :205-213
[7]   The 2014 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma Definition of Grading Patterns and Proposal for a New Grading System [J].
Epstein, Jonathan I. ;
Egevad, Lars ;
Amin, Mahul B. ;
Delahunt, Brett ;
Srigley, John R. ;
Humphrey, Peter A. .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2016, 40 (02) :244-252
[8]   Is robotically assisted laparoscopic radical prostatectomy less invasive than retropubic radical prostatectomy? Results from a prospective, unrandomized, comparative study [J].
Fracalanza, Simonetta ;
Ficarra, Vincenzo ;
Cavalleri, Stefano ;
Galfano, Antonio ;
Novara, Giacomo ;
Mangano, Angelo ;
Plebani, Mario ;
Artibani, Walter .
BJU INTERNATIONAL, 2008, 101 (09) :1145-1149
[9]   Rehospitalization after Radical Prostatectomy in a Nationwide, Population Based Study [J].
Frioriksson, Jon Om ;
Holmberg, Erik ;
Adolfsson, Jan ;
Lambe, Mats ;
Bill-Axelson, Anna ;
Carlsson, Stefan ;
Hugosson, Jonas ;
Stattin, Par .
JOURNAL OF UROLOGY, 2014, 192 (01) :112-119
[10]  
Fukuda H, 2000, PROSTATE, V44, P322