LYP3, a New Bestatin Derivative for Aminopeptidase N Inhibition

被引：8

作者：

Luan, Yepeng ^{[1
]}

Ma, Chunhua ^{[1
]}

Sui, Zhongguo ^{[2
]}

Wang, Xuejian ^{[1
]}

Feng, Jinhong ^{[1
]}

Liu, Ning ^{[1
]}

Jing, Fanbo ^{[2
]}

Wang, Yan ^{[1
]}

Li, Minyong ^{[1
]}

Fang, Hao ^{[1
]}

Xu, Wenfang ^{[1
]}

机构：

[1] Shandong Univ, Sch Pharmaceut Sci, Inst Med Chem, Jinan 250012, Shandong, Peoples R China

[2] Qingdao Univ, Affilated Hosp, Dept Pharm, Qingdao 266003, Shandong, Peoples R China

来源：

MEDICINAL CHEMISTRY | 2011年 / 7卷 / 01期

关键词：

Aminopeptidase N; bestatin; tumorigenesis; A549; ES-2; MDA-MB-231;

D O I：

10.2174/157340611794072706

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Aminopeptidase N (APN) is a ubiquitous enzyme overexpressed on tumor cells and plays an important role in angiogenesis and metastasis of tumor. Bestatin as an effective inhibitor of aminopeptidase N is used for complementary treatment of cancer with other drugs. In this work, we reformed the structure of bestatin to a new derivative LYP3 to improve the water solubility and effectiveness. The inhibitory activity of LYP3 against APN was evaluated in vitro.

引用

页码：32 / 36

页数：5

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