Effect of ABCB1 (MDR1) 3435C>T polymorphism on salivary secretion of carbamazepine

被引：0
作者：
Kurzawski, Mateusz [1 ]
Bartnicka, Lilianna [1 ]
Drodzik, Agnieszka [2 ]
Bialecka, Monika
Drozdzik, Marek [1 ]
机构：
[1] Pomeranian Med Univ, Dept Pharmacol, PL-70111 Szczecin, Poland
[2] Pomeranian Med Univ, Dept Periodontol, PL-70111 Szczecin, Poland
来源：
PHARMACOLOGICAL REPORTS | 2007年 / 59卷
关键词：
ABCB1; polymorphism; P-glycoprotein; carbamazpine; salivary secretion;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The aim of the present study was to evaluate the effects of ABCB1 (MDR1) gene polymorphism on salivary secretion of carbamazcpine. The study was carried out on 51 patients diagnosed with epilepsia medicated with carbamazepine. ABCB1 polymorphism was evaluated using PCR-RFLP methods. Carbamazepine concentrations were measured in blood serum as well as in saliva using FPIA method. Evaluation of the impact of ABCB1 3435C > T polymorphism on salivary carbamazepine secretion did not reveal any significant influence of the genotype. Mean value of Pearson's correlation coefficient was 0.787. There was a trend towards higher values of the coefficient in ABCB1 gene 3435CC carriers (0.855) as compared to 3435CT (0.684) and 3435TT (0.672) subjects. It can be stated that ABCB1 gene polymorphism does not affect salivary carbamazepine secretion.
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页码：275 / 279
页数：5
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