A tandem Heck-carbocyclization/Suzuki-coupling approach to the stereoselective syntheses of asymmetric 3,3-(diarylmethylene)indolinones

被引：110

作者：

Cheung, WS ^{[1
]}

Patch, RJ ^{[1
]}

Player, MR ^{[1
]}

机构：

[1] Johnson & Johnson Pharmaceut Res & Dev LLC, Drug Discovery, Cranbury, NJ 08512 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 70卷 / 09期

关键词：

D O I：

10.1021/jo050016d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and versatile method for stereoselective synthesis of (E)-3,3-(diarylmethylene)indolinones by a palladium-catalyzed tandem Heck-carbocyclization/Suzuki-coupling sequence is presented. Factors influencing yield and selectivity, namely catalyst, coordinating ligand, and solvent, are detailed.

引用

页码：3741 / 3744

页数：4

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