Solvent effects on stereoselectivity in 2,3-dimethyl-4-chromanone cyclization by quinine-catalyzed asymmetric intramolecular oxo-Michael addition

被引：21
|
作者：
Tanaka, T [1 ]
Kumamoto, T [1 ]
Ishikawa, T [1 ]
机构：
[1] Chiba Univ, Fac Pharmaceut Sci, Chiba 2638522, Japan
来源：
TETRAHEDRON-ASYMMETRY | 2000年 / 11卷 / 23期
关键词：
D O I：
10.1016/S0957-4166(00)00461-4
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Examination of the quinine-catalyzed asymmetric intramolecular oxo-Michael addition of o-tigloylphenol in various solvents led to high stereoselectivity in chromanone cyclization when chlorobenzene was used as a solvent, giving cis-2,3-dimethyl-4-chromanone with 60% de and 98% ee. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：4633 / 4637
页数：5
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