Suzuki-miyaura cross-coupling approach to 3,4-diaryl-3-pyrrolin-2-ones from tetramic acid triflates

被引：14
作者：
Dorward, Kathryn M. [1 ]
Guthrie, Nicolette J. [1 ]
Pelkey, Erin T. [1 ]
机构：
[1] Hobart & William Smith Coll, Dept Chem, Geneva, NY 14456 USA
来源：
SYNTHESIS-STUTTGART | 2007年 / 15卷 / 15期
关键词：
lactams; Suzuki-Miyaura cross-couplings; arylations; 3-pyrrolin-2-ones; tetramic acids;
D O I：
10.1055/s-2007-983778
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A three-step approach to 4-aryl-3-phenyl-3-pyrrolin-2ones from a readily available tetramic acid is described. The introduction of different aryl groups to the 4-position of the ring system was accomplished utilizing Suzuki-Miyaura cross-coupling reactions of the corresponding tetramic acid triflate. This strategy was successfully employed in the first synthesis of the NH lactam analogue of rofecoxib.
引用
收藏
页码：2317 / 2322
页数：6
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